DISEASE CATEGORY: Hepatic INDICATION: Liver disease Targeting the cGAS-IRF3 signaling pathway by inhibiting cGAS or the gap junction protein GJB1 could treat alcohol-related liver disease. In liver samples from alcoholic-related liver disease patients, high cGAS...

Neurology INDICATION: Neuropathy Mouse studies suggest GJB1 could help treat Charcot-Marie-Tooth type 1X (CMT1X), a disease caused by GJB1 mutations. In a GJB1-knockout mouse model of CMT1X, intrathecal injection of a viral vector encoding GJB1...

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hepatic disease Drug-induced liver toxicity (DILI) Gap junction protein b1, 32 kDa (GJB1; CX32; connexin-32) Mouse studies identified a small molecule inhibitor of CX32 that could...

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In two sets of gene and protein expression data...

INNX became the exclusive European distributor for TWTI's Invader molecular diagnostic products for genetic testing of certain risk factors for cardiovascular and hearing disorders, including Factor II (prothrombin), Factor V (Leiden), and Connexin 26. Under...

Innogenetics (Euronext:INNX) became the exclusive European distributor for TWTI's Invader molecular diagnostic products for genetic testing of certain risk factors for cardiovascular and hearing disorders, including Factor V (Leiden), Factor II (prothrombin), and Connexin 26....