BioCentury | Aug 1, 2019
Distillery Therapeutics

Tumor-penetrating camptothecin conjugate for liver, pancreatic cancers

...generic TOP1 inhibitor camptothecin linked to neutrally charged γ-glutamyl polymers that are converted by tumor-expressed GGT...
...mouse model of pancreatic cancer, the conjugate prevented tumor relapse and extended survival. TARGET/MARKER/PATHWAY: ϒ-glutamyltransferase (GGT...
...email: guzhen@ucla.edu CONTACT: Youqing Shen, Zhejiang University, Hangzhou, China email: shenyq@zju.edu.cn Inhua Muijrers-Chen Heredity pancreatic cancer panel ZenCapsule Inc. Gamma-glutamyltransferase (GGT) Topoisomerase...
BioCentury | Jul 25, 2019
Clinical News

July 25 Clinical Quick Takes: J&J’s ponesimod hits MS endpoint; plus a CRISPR first, Genkyotex and Aeglea

...twice-daily 400 mg dose group met the primary endpoint of reduction in γ glutamyl transpeptidase (GGT...
BioCentury | Jun 11, 2019
Clinical News

CymaBay down on Phase IIb NASH miss

...high dose of seladelpar vs. 8.9% for placebo (p<0.0001), and 43.1% for gamma glutamyl transferase (GGT...
BioCentury | Nov 9, 2018
Clinical News

Twice-daily dose of Genkyotex's PBC therapy meets six-week endpoints

...showing that twice-daily GKT831 led to a significant 23% reduction in mean γ glutamyl transpeptidase (GGT...
...primary endpoint of the trial is evaluating the change from baseline to week 24 in GGT...
...inhibitor Indication: Treat primary biliary cholangitis (PBC) Endpoint: Change from baseline in γ glutamyl transpeptidase (GGT...
BioCentury | Nov 5, 2018
Clinical News

Twice-daily dose of Genkyotex's PBC therapy meets six-week endpoints

...showing that twice-daily GKT831 led to a significant 23% reduction in mean γ glutamyl transpeptidase (GGT...
...primary endpoint of the trial is evaluating the change from baseline to week 24 in GGT...
BioCentury | Jun 22, 2018
Clinical News

Sarepta's DMD candidate leads to microdystrophin expression of 76.2% in Phase I/IIa

...in the trial, which is enrolling about 12 patients. Two patients had elevated gamma-glutamyl transferase (GGT...
BioCentury | Jun 19, 2018
Clinical News

Sarepta hits high on Phase I/IIa DMD readout

...in the trial, which is enrolling about 12 patients. Two patients had elevated gamma-glutamyl transferase (GGT...
BioCentury | Apr 20, 2018
Clinical News

Intercept's Ocaliva improves fibrosis in subgroup of primary biliary cholangitis patients

...alkaline phosphatase, total bilirubin, direct bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT...
BioCentury | Apr 13, 2018
Clinical News

CymaBay reports additional Phase II data for seladelpar

...phosphatase levels at week 8 and safety; aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT...
BioCentury | Jul 21, 2017
Clinical News

CymaBay reports Phase II data for lower doses of seladelpar in PBC

...and safety. Secondary endpoints include measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT...
...phosphatase levels at week 8 and safety; aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT...
Items per page:
1 - 10 of 35