BioCentury | May 23, 2019
Financial News

How Bicycle, Ideaya fared in debuts as they join 2019’s growing IPO class

...Phase I/II basket trial of lead program IDE196 to treat solid tumors harboring GNAQ or GNA11...
...Tuesday (see "Merck Bets on HIF2As with Peloton Takeout Ahead of Planned Listing" ). Targets: GNA11...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...in thyroid cancer; FAT1 in esophageal cancer and head and neck cancer; and GαQ and GNA11...
...known. Targets: FAT1 - FAT Atypical Cadherin 1; GαQ (GNAQ) - G protein q polypeptide; GNA11...
...Writer Bayer AG Inventiva S.A. Kyowa Hakko Kirin Co. Ltd. Roche University of Bristol Vivace Therapeutics Inc. G protein q polypeptide (G-ALPHA-q) (GNAQ) G protein subunit alpha 11 (GNA11) Large...
BioCentury | Mar 13, 2018
Distillery Techniques

Disease models

...TECHNOLOGY: Transgenics and knockouts BAP1-knockout, transgenic mice with melanocyte-specific expression of mutant human GNA11 could be...
...for metastatic uveal melanoma. Mice with systemic BAP1 knockout and tamoxifen-induced expression of the human GNA11...
...Mice with BRCA1-associated protein 1 (BAP1) knockout expressing mutant human G protein subunit α 11 (GNA11...
BioCentury | Nov 16, 2017
Emerging Company Profile

YAP off, YAP on

...and proliferation. About 85% of uveal melanomas have activating mutations in the G-proteins GαQ and GNA11...
...Calif. Vivace Therapeutics Inc., San Mateo, Calif. Targets GαQ (GNAQ) - G protein q polypeptide GNA11...
BioCentury | Nov 15, 2016
Distillery Techniques

Chemistry

...of Medicine at Mount Sinai University of North Carolina at Chapel Hill Arrestin beta 2 (ARRB2) Dopamine D2 receptor G protein subunit alpha 11 (GNA11)...
BioCentury | Apr 7, 2016
Distillery Therapeutics

Therapeutics: G protein subunit α 11 (GNA11); uncoupling protein 1 mitochondrial proton carrier (UCP1)

...inhibiting GNA11 could help treat obesity. In white adipocytes from obesity patients, high levels of GNA11...
...include testing GNA11 inhibitors in animal models of obesity. TARGET/MARKER/PATHWAY: G protein subunit α 11 (GNA11...
BioCentury | Feb 12, 2009
Targets & Mechanisms

New shock treatment

...epinephrine, the standard of care. If a selective inhibitor for the two proteins, GNAQ and GNA11...
...in anaphylaxis: G protein q polypeptide (GNAQ; Gaq) and G protein a11 ( Gq class ) (GNA11...
...endothelial cells. Next, the team generated mice with endothelial cells deficient in both GNAQ and GNA11...
BioCentury | Feb 5, 2009
Distillery Therapeutics

Indication: Inflammation

...Licensing status Publication and contact information Inflammation Anaphylaxis Guanine nucleotide-binding protein (G protein) a11 (Gq class) (GNA11...
...GNA11); G protein q polypeptide (GNAQ; Gaq) Studies in mice suggest that targeting GNAQ and GNA11...
...could help treat anaphylactic shock. In mice with endothelial cell-specific knockout of both Gnaq and Gna11...
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