BioCentury | Aug 28, 2020
Distillery Therapeutics

Preventing thrombosis using nanoparticles loaded with anti-G protein peptides

...injuryNanoparticles loaded with a peptide inhibitor of GNA13...
...core with a sequence derived from GPIIIa’s GNA13-binding...
...microvascular thrombosis in mice with myocardial ischemia–reperfusion injury.TARGET/MARKER/PATHWAY: G protein alpha 13 (GNA13)...
BioCentury | Feb 8, 2017
Distillery Therapeutics

Musculoskeletal

...INDICATION: Osteoporosis; bone repair Cell culture and mouse studies suggest GNA13 could help treat osteoporosis and...
...osteoclast cell-based assay of bone resorption, an adeno-associated viral (AAV) vector-encoded constitutively active form of GNA13...
...include testing systemic delivery of GNA13 with bone-tropic viral vectors. TARGET/MARKER/PATHWAY: G protein α 13 (GNA13...
BioCentury | Nov 21, 2013
Distillery Therapeutics

Indication: Cardiovascular disease

...disease Thrombosis Integrin b3 (GPIIIa; CD61); G protein alpha 13 (GNA13) Mouse studies suggest selectively inhibiting CD61 interactions with GNA13...
...marketed CD61 antagonists. In mouse thrombosis assays, a peptide inhibitor that selectively blocked binding of Gna13...
BioCentury | Nov 21, 2013
Targets & Mechanisms

Riding the integrin wave in thrombosis

...of the protein complex and triggers platelet adhesion. In a second wave, another adaptor protein, G protein alpha 13 (GNA13)...
...motif on the C terminus of integrin b 3 , the EXE motif, that mediated GNA13...
...but talin is displaced byG protein alpha 13 ( GNA13 ) [ c ]. Inhibiting GNA13...
BioCentury | Feb 5, 2009
Distillery Therapeutics

Indication: Inflammation

...decreases, hypothermia and death compared with what was seen in wild-type or individual Gna12 or Gna13...
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