BioCentury | Jan 9, 2019
Distillery Therapeutics

Cardiovascular

...cell function, compared with wild-type GRK2 expression. Also in the model, knock-in of the mutant GRK2...
...testing small molecules that inhibit GRK2 localization to the mitochondria of cardiomyocytes. TARGET/MARKER/PATHWAY: G protein-coupled receptor kinase 2 (GRK2; GPRK2...
...2018 doi:10.1126/scisignal.aau0144 CONTACT: Walter J. Koch, Temple University, Philadelphia, Pa. email: walter.koch@temple.edu Sandi Wong Temple University G protein-coupled receptor kinase 2 (GRK2) (GPRK2) Ischemia/reperfusion...
BioCentury | Sep 20, 2018
Distillery Therapeutics

Infectious disease

...INDICATION: Influenza virus Cell culture and mouse studies suggest inhibiting GRK2 could help treat influenza A...
...for anxiety, depression, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). TARGET/MARKER/PATHWAY: G protein-coupled receptor kinase 2 (GRK2; GPRK2...
...Silke Stertz, University of Zurich, Zurich, Switzerland email: stertz.silke@virology.uzh.ch Claire Quang Paxil, Seroxtat, paroxetine University of Zurich G protein-coupled receptor kinase 2 (GRK2) (GPRK2) Influenza...
BioCentury | Jul 25, 2017
Distillery Therapeutics

Cardiovascular

...identified a methyltriazole-based GRK2 inhibitor that could help treat heart failure. Previous studies have shown GRK2...
...Ltd. could include testing the compound in animal models of heart failure. TARGET/MARKER/PATHWAY: G protein-coupled receptor kinase 2 (GRK2; GPRK2...
...Ltd., Fujisawa, Japan email: tomohiro.okawa@takeda.com Elizabeth S. Eaton Takeda Pharmaceutical Co. Ltd. Adrenergic receptor beta 2 (ADRB2) G protein-coupled receptor kinase 2 (GRK2) (GPRK2) Heart...
BioCentury | Jul 20, 2017
Preclinical News

Paper: GRK2 inhibitors could treat heart failure

...GRK2 ; GPRK2) inhibitors that could help treat heart failure. Previous studies had shown reduced GRK2...
...Takeda identified inhibitors of GRK2 kinase activity, then produced a lead compound that bound to GRK2...
...a mouse cardiomyocyte-based model. Elizabeth S. Eaton GlaxoSmithKline plc Takeda Pharmaceutical Co. Ltd. Adrenergic receptor beta 2 (ADRB2) G protein-coupled receptor kinase 2 (GRK2) (GPRK2...
BioCentury | Mar 29, 2017
Distillery Therapeutics

Cardiovascular

...INDICATION: Heart failure In vitro and cell culture studies identified a GRK2 -inhibiting analog of Paxil...
...to treat anxiety, depression, obsessive compulsive disorder (OCD) and post-traumatic stress disorder. TARGET/MARKER/PATHWAY: G protein-coupled receptor kinase 2 (GRK2; GPRK2...
...Scott D. Larsen, University of Michigan, Ann Arbor, Mich. email: sdlarsen@med.umich.edu Hongjiang Li University of Michigan G protein-coupled receptor kinase 2 (GRK2) (GPRK2...
BioCentury | Mar 31, 2016
Distillery Therapeutics

Therapeutics: G protein-coupled receptor kinase 2 (GRK2; GPRK2)

...Cardiovascular disease INDICATION: Heart failure Mouse studies suggest a peptide derived from GRK2 could help treat...
...failure, transgenic cardiac-specific expression of a peptide from the G protein signaling domain of bovine GRK2...
...include promoting expression of the peptide in additional models of heart failure. TARGET/MARKER/PATHWAY: G protein-coupled receptor kinase 2 (GRK2; GPRK2...
BioCentury | Feb 13, 2014
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer G protein-coupled receptor kinase 3 (GRK3; ADRBK2) Mouse and human sample studies suggest inhibiting ADRBK2 could help suppress prostate...
BioCentury | Jun 30, 2011
Distillery Therapeutics

Indication: Cancer

...Cancer Cancer G protein-coupled receptor kinase 2 (GRK2; GPRK2); casein kinase 1a (CSNK1A; CKI-a) Cell culture studies suggest antagonizing GRK2...
...cancers driven by activation of smoothened (SMO). In cell culture, small hairpin RNA knockdown of GRK2...
...decreased oncogenic SMO phosphorylation compared with vector treatment. Also in cell culture, mutations that blocked GRK2...
BioCentury | Jun 30, 2011
Targets & Mechanisms

Smoother tumor targets

...Texas researchers have identified two kinases- GRK2 and CKI-a-that are responsible for phosphorylating smoothened , the...
...front against the tumor-promoting pathway if sufficiently selective inhibitors can be developed. Because G protein-coupled receptor kinase 2 (GRK2; GPRK2...
...cell surface [ a ] can be phosphorylated by two kinases, G protein-coupled receptor kinase 2 ( GRK2 ; GPRK2...
BioCentury | Apr 28, 2011
Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Genetic mouse model of attention deficit hyperactivity disorder (ADHD) Mice lacking a gene linked to ADHD could be used to help...
Items per page:
1 - 10 of 19