07:00 , Aug 11, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: G protein-coupled receptor 91 (GPR91, SUCNR1)

Autoimmune disease INDICATION: Rheumatoid arthritis Cell culture, patient sample and mouse studies suggest inhibiting GPR91 could help treat rheumatoid arthritis. In bone marrow-derived mouse macrophages cultured in synovial fluid from RA patients, GPR91 knockout decreased secretion of...
07:00 , Oct 16, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Autoimmune disease ...
07:00 , Oct 16, 2008 |  BC Innovations  |  Targets & Mechanisms

GPR91 Goes Local

GPR91 is a key player in autoimmune disease, transplant rejection and diabetic retinopathy, according to new findings emerging from both pharmaceutical and academic laboratories. Taken together, the research suggests targeting the G protein-coupled receptor may...
07:00 , Oct 16, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Ophthalmic disease ...
07:00 , Jun 26, 2008 |  BC Innovations  |  Targets & Mechanisms

Reining in Renin

Although antihypertensives have become the standard of care in diabetic nephropathy, the mechanistic link between hyperglycemia and blood pressure, as well as between hyperglycemia and potential downstream renal damage, has remained elusive.1 A paper published in...
07:00 , Jun 19, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Renal disease ...
07:00 , May 17, 2004 |  BC Week In Review  |  Company News

Tularik other research news

Researchers published in Nature that the orphan G protein-coupled receptor (GPCR) GPR91 functions as a receptor for succinate. GPR91-deficient mice were not susceptible to succinate-induced hypertension. The researchers suggest that the results indicate a possible...