20:09 , Aug 1, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Addiction In vitro, rat and mouse studies identified a brain-penetrating GPR88 agonist that could help treat alcohol addiction. Previous studies in a mouse model of alcohol addiction have shown that knockout of GPR88 increased alcohol...
21:43 , Jul 12, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: June 2018

New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other molecule...
17:52 , Jun 28, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Addiction Rat studies suggest agonizing GPR139 could help treat alcohol addiction. In a rat model of alcohol dependence, oral administration or intracerebral injection into the habenula of a tool compound GPR139 agonist decreased alcohol intake...
19:55 , Jun 27, 2018 |  BC Extra  |  Preclinical News

Targeting a GPCR for alcohol addiction

Researchers at The Scripps Research Institute identified a GPCR in a brain region associated with drug and alcohol addiction as a new molecular target that could help treat alcohol abuse. In a paper published in eNeuro,...
23:17 , May 24, 2018 |  BC Innovations  |  Product R&D

Bias-less bispecifics

Taking a leaf from the small molecule playbook, cancer play Merus N.V. is bringing unbiased screening to the bispecifics space. The biotech is betting the approach can discover bispecific antibodies with novel activity against known...
20:45 , May 2, 2018 |  BC Innovations  |  Distillery Techniques

Chemistry; drug platforms

TECHNOLOGY: Tool compounds; structural analyses Structural analysis of a peptide inhibitor bound to the cysteine-rich domain (CRD) of FZD7 could guide the development of small molecule FZD7 inhibitors, and the peptide could be used to probe...
22:00 , Mar 22, 2018 |  BC Innovations  |  Strategy

Janssen’s virtual discovery

In the latest example of how AI can accelerate drug discovery, Janssen has shown it can use machine learning to create virtual drug screens that outperform conventional assays. The most promising application may be in...
19:06 , Feb 21, 2018 |  BC Innovations  |  Distillery Therapeutics

Gastrointestinal

INDICATION: Gastrointestinal Patient sample and mouse studies identified a BBC3 inhibitor that could help treat intestinal injury caused by topoisomerase inhibitors for cancer. In mice receiving the generic topoisomerase inhibitor irinotecan, BBC3 knockout increased survival compared...
23:13 , Jan 25, 2018 |  BC Innovations  |  Strategy

Takeda rides Denali’s ATV

In its deal with Denali, Takeda has not only boosted its CNS pipeline, but also gained access to a delivery technology that could open the door to a host of CNS targets only druggable with...
20:04 , Jan 4, 2018 |  BC Innovations  |  Translation in Brief

Designing specificity

Solving a key problem in the orexin field, C4X Discovery Holdings plc (LSE:C4XD) has described how its technology platform yielded an antagonist with selectivity for OX1R over OX2R and disclosed data for the compound in...