BC Innovations | Nov 19, 2015
Distillery Therapeutics

Therapeutics: G protein-coupled receptor 3 (GPR3)

Neurology INDICATION: Alzheimer's disease (AD) Studies in patient samples and mice suggest inhibiting GPR3 could help treat AD. Brain levels of GPR3 were higher in postmortem brain tissue samples from AD patients than in samples...
BC Innovations | Dec 13, 2012
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) Arrestin b2 (ARRB2) In vitro and mouse studies suggest antagonizing ARRB2 could help treat AD. In vitro, ARRB2 coimmunoprecipitated with g-secretase, a...
BC Innovations | Dec 6, 2012
Targets & Mechanisms

Thinking outside the amyloid box

Two European groups have proposed strategies for treating Alzheimer's disease that are focused on hitting intermediate protein fragments and enzymatic steps in the pathway that produces b-amyloid . 1,2 A team at Institut National de la...
BC Innovations | Sep 16, 2010
Targets & Mechanisms

Introducing GSAP

Following a lead provided by Gleevec , a team of U.S. researchers from The Rockefeller University and Intra-Cellular Therapies Inc. has identified a new regulatory protein, g-secretase activating protein, that activates g-secretase, a key Alzheimer's disease...
BioCentury | Aug 23, 2010
Product Development

Gamma no-go

The safety signals seen in Eli Lilly and Co. 's Phase III trials of semagacestat for Alzheimer's disease lend support to researchers who believe antagonizing gamma secretase is not the right approach to AD. However,...
BC Innovations | Feb 26, 2009
Cover Story

Genentech's new parADigm

A study by a team at Genentech Inc. proposes a new mechanism for Alzheimer's disease pathogenesis by outlining a process that could be an early step in the neurodegenerative disorder. 1 The work also identifies...
BC Innovations | Feb 26, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) G protein-coupled receptor 3 (GPR3) A study in cell culture and in mice suggests inhibiting GPR3...
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