BioCentury | Jan 8, 2015
Distillery Therapeutics

Therapeutics: PA-I galactophilic lectin (lecA); fucose-binding lectin PA-ILL (lecB)

...glycosylated ligands, resulting in molecules that exhibited nanomolar binding affinities for P. aeruginosa lecA and lecB...
...and identifying a viable method of administration. TARGET/MARKER/PATHWAY: PA-I galactophilic lectin (lecA); fucose-binding lectin PA-ILL (lecB...
BioCentury | Jan 29, 2009
Targets & Mechanisms

Breaking the biofilm barrier

...that dendrimers targeting the fucose-binding lectin PA-IIL (lecB) may be up to the task. Like other lectins, lecB...
...known virulence factor of P. aeruginosa , plays a role in biofilm formation. However, because lecB...
...unclear whether it would be a good individual target. Reymond's group has now shown that lecB-targeting...
BioCentury | Jan 15, 2009
Distillery Therapeutics

Indication: Infectious disease

...Publication and contact information Infectious disease Pseudomonas Fucose-binding lectin PA-IIL (lecB) A study in cell culture identified lecB-binding...
...form biofilms that protect it from antibiotics. In a P. aeruginosa biofilm inhibition assay, the lecB-binding...
...55% at 10 mM. FD2 also dispersed established biofilms with greater efficacy than a reference lecB...
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