BC Innovations | Nov 5, 2009
Targets & Mechanisms

Norrin vs. VEGF

Two papers in Cell describe a new signaling pathway that acts upstream of VEGF to control vascular development in the embryonic retina. The pathway is also present in adults, but the question is whether it's...
BC Innovations | Nov 5, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Various indications Frizzled homolog 4 (FZD4); Norrie disease pseudoglioma (NDP; Norrin) Studies in mice suggest that antagonizing NDP or FZD4 could help treat diseases...
BC Innovations | Nov 5, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Various indications Frizzled homolog 4 (FZD4); tetraspanin 12 (TSPAN12) Studies in mice and in human cell culture suggest that targeting TSPAN12 could help treat...
BC Week In Review | Aug 19, 2002
Company News

Xenon Genetics Inc. other research news

Researchers published in Nature Genetics that FZD4 plays a role in the etiology of FEVR. Mutations in FZD4 segregated completely with affected individuals from one large multigenerational family and were detected in affected individuals from...
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