08:00 , Nov 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Various indications Frizzled homolog 4 (FZD4); Norrie disease pseudoglioma (NDP; Norrin) Studies in mice suggest that antagonizing NDP or FZD4 could help treat diseases...
08:00 , Nov 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Various indications Frizzled homolog 4 (FZD4); tetraspanin 12 (TSPAN12) Studies in mice and in human cell culture suggest that targeting TSPAN12 could help treat...
08:00 , Nov 5, 2009 |  BC Innovations  |  Targets & Mechanisms

Norrin vs. VEGF

Two papers in Cell describe a new signaling pathway that acts upstream of VEGF to control vascular development in the embryonic retina. The pathway is also present in adults, but the question is whether it's...
07:00 , Aug 19, 2002 |  BC Week In Review  |  Company News

Xenon Genetics Inc. other research news

Researchers published in Nature Genetics that FZD4 plays a role in the etiology of FEVR. Mutations in FZD4 segregated completely with affected individuals from one large multigenerational family and were detected in affected individuals from...