BioCentury | May 1, 2020
Distillery Therapeutics

The lipids LXA4 and RvD1 as treatment for E. coli pneumonia

DISEASE CATEGORY: Infectious disease INDICATION: Escherichia; pneumonia The lipids LXA4 and RvD1, ligands of the membrane receptor FPRL1, could treat E. coli pneumonia by promoting antibacterial functions in neutrophils. The release of neutrophil elastase, induced...
BioCentury | Jun 13, 2018
Translation in Brief

Quorum sensitivity

...al. “Designer cells programming quorum-sensing interference with microbes.” Nature Communications (2018) Jaime de León, Staff Writer ETH Zurich Formyl peptide receptor 1 (FPR1) pfs...
BioCentury | Jun 13, 2018
Distillery Therapeutics

Infectious disease

...cells are generated by transfecting HEK cells with two constructs: a sensor unit, based on formyl peptide receptor 1 (FPR1)...
...8, 2018 doi:10.1038/s41467-018-04223-7 CONTACT: Martin Fussenegger, ETH Zurich, Zurich, Switzerland email: martin.fussenegger@bsse.ethz.ch Jaime De Leon Cell Therapy ETH Zurich Formyl peptide receptor 1 (FPR1) pfs...
BioCentury | Feb 22, 2017
Distillery Therapeutics

Cardiovascular

...INDICATION: Myocardial infarction (MI) Mouse studies suggest dual FPR1 / FPRL1 agonists could help treat MI...
...could help treat MI. In primary rat and mouse cardiomyocyte-based models of ischemia/reperfusion, a dual FPR1/FPRL1...
...Next steps include identifying and testing additional dual FPR1/FPRL1 agonists in models of MI. TARGET/MARKER/PATHWAY: Formyl peptide receptor 1 (FPR1)...
BioCentury | Aug 21, 2014
Distillery Therapeutics

Indication: Dermatology

...Dermatology Dermatology Annexin A1 (ANXA1); formyl peptide receptor 1 (FPR1) Cell culture studies suggest inhibiting ANXA1 or its receptor FPR1...
...or FPR1 blocked supernatant-induced cytotoxicity in keratinocytes. Ongoing work includes identifying small molecules that antagonize FPR1-induced...
BioCentury | Oct 17, 2013
Distillery Therapeutics

Indication: Infectious disease

...status Publication and contact information Infectious disease Infectious disease Formyl peptide receptor 1 (FPR1) Mouse studies suggest stimulating neutrophil-expressed FPR1...
...other chronic gastrointestinal infections. In a mouse model of Toxoplasma gondii-related gastrointestinal infection, deletion of Fpr1...
...no deletion. Next steps could include exploring the therapeutic potential of N-formyl peptide-mediated stimulation of FPR1...
BioCentury | Sep 19, 2013
Distillery Therapeutics

Indication: Neurology

...information Neurology Pain Formyl peptide receptor 1 (FRP1); a-hemolysin (aHL) Mouse and cell culture studies suggest targeting bacterial FPR1...
...compared with saline. In these models, aHL-deficient bacteria caused less hypersensitivity than wild-type bacteria. In Fpr1-deficient...
BioCentury | Sep 19, 2013
Targets & Mechanisms

Bacteria's painful truth

...formyl-methionyl-isoleucyl-phenylalanine-leucine (FMIFL) was the heat-resistant factor from S. aureus and established that FMIFL interacts with formyl peptide receptor 1 (FPR1)...
...by the paper are the bacterial proteins FMIFL and aHL or their points of entry, FPR1...
BioCentury | Mar 14, 2013
Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Asthma Formyl peptide receptor-like 1 (FPRL1; FPR2) Cell culture studies suggest agonizing FPR2 in innate immune cells could be useful for treating asthma. Patients with...
BioCentury | Feb 18, 2013
Emerging Company Profile

Signum: Rosacea double play

Therapies on the market or in development for rosacea treat either the symptomatic flushing or the inflammatory skin lesions. Signum Dermalogix Inc. 's lead small molecule isoprenylcysteine analog could treat both aspects of rosacea by...
Items per page:
1 - 10 of 17