21:13 , Jun 13, 2018 |  BC Innovations  |  Translation in Brief

Quorum sensitivity

By engineering HEK cells with machinery to produce and secrete quorum-sensing molecules, an ETH Zurich team has developed microbe-sensing technology it believes could prevent the development of drug resistance by reducing biofilm formation and possibly...
18:22 , Jun 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Candida HEK cells engineered to synthesize and secrete bacterial AI-2 could help treat candidiasis. The cells are generated by transfecting HEK cells with two constructs: a sensor unit, based on formyl peptide receptor 1...
19:07 , Feb 22, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Myocardial infarction (MI) Mouse studies suggest dual FPR1 / FPRL1 agonists could help treat MI. In primary rat and mouse cardiomyocyte-based models of ischemia/reperfusion, a dual FPR1/FPRL1 agonist tool compound decreased levels of the...
07:00 , Aug 21, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Dermatology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Dermatology Dermatology Annexin A1 (ANXA1); formyl peptide receptor 1 (FPR1) Cell culture studies suggest inhibiting ANXA1 or its receptor FPR1 could help treat drug-induced adverse cutaneous...
07:00 , Oct 17, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Infectious disease Formyl peptide receptor 1 (FPR1) Mouse studies suggest stimulating neutrophil-expressed FPR1 could help treat toxoplasmosis and other chronic...
07:00 , Sep 19, 2013 |  BC Innovations  |  Targets & Mechanisms

Bacteria's painful truth

In a surprise finding likely to alter how neurologists, immunologists and microbiologists view infection-associated pain, a group at Boston Children's Hospital has shown that bacteria can directly trigger action potentials in pain fibers, leading to...
07:00 , Sep 19, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Formyl peptide receptor 1 (FRP1); a-hemolysin (aHL) Mouse and cell culture studies suggest targeting bacterial FPR1 agonists and aHL could help treat infection-induced pain....