20:48 , Dec 19, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting the BRD4-FOXO3-CDK6 axis could help treat luminal breast cancer resistant to AKT inhibitors. In patients who had been treated for hormone receptor-positive luminal...
08:00 , Feb 28, 2013 |  BC Innovations  |  Targets & Mechanisms

Making TRAIL

Researchers at the Penn State Milton S. Hershey Medical Center have identified a small molecule inducer of TRAIL expression that has antitumor effects in multiple mouse models. 1 Oncoceutics Inc. has licensed the findings and...
07:00 , May 31, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Colorectal cancer b-Catenin (CTNNB1); forkhead box O3 (FOXO3; FOXO3a); phosphoinositide 3-kinase (PI3K); protein kinase B (PKB; PKBA; AKT; AKT1) Patient and cell studies suggest inhibiting...
08:00 , Feb 18, 2010 |  BC Innovations  |  Targets & Mechanisms

Turning up the heat on HD

Researchers at Duke University have found small molecules that help cells untangle aggregates of the misfolded protein thought to cause Huntington's disease. 1 The molecules are now the lead compounds for Chaperone Therapeutics Inc. ,...
07:00 , Aug 27, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact nformation Cardiovascular disease Cardiac hypertrophy Sirtuin 3 (SIRT3); forkhead box O3 (FOXO3A) Studies in mice suggest that increasing SIRT3 expression could be useful for preventing cardiac hypertrophy....
07:00 , Jul 9, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Forkhead box O3 (FOXO3; FOXO3A) Studies in invertebrates and in tissue culture suggest that increasing psammaplin A (PA) or FOXO3A levels could be useful...