22:41 , Apr 27, 2017 |  BC Innovations  |  Targets & Mechanisms

Selective senescence

A group at the Erasmus University Rotterdam has devised a strategy for inducing apoptosis only in senescent cells, and used it to create a cell-permeable peptide that it hopes to take to the clinic to...
15:45 , Apr 12, 2017 |  BC Innovations  |  Distillery Therapeutics

Hepatic; renal

INDICATION: Hepatic; renal failure Cell culture and mouse studies suggest inhibiting FOXO4 could help treat drug-induced liver toxicity and age-related renal dysfunction. In a mouse model of doxorubicin-induced hepatotoxicity, a cell-permeable peptide that inhibits FOXO4 decreased...
18:48 , Mar 28, 2017 |  BC Extra  |  Clinical News

Peptide kills senescent cells, reverses chemo toxicity in mice

Researchers identified a therapeutic peptide that could be used to kill senescent cells, which are associated with a variety of aging-related disorders, and thereby rejuvenate animals and reduce the toxic effects of chemotherapy. The group,...