BioCentury | Jun 1, 2019
Product Development

ASCO 2019 abstracts show solid tumor race heating up among bispecifics and CAR Ts

...Research Institute (TGen) e21516 PAX7-FOXO1 oncogenic fusion protein Rhabdomyosarcoma Paired box gene 7 (PAX7) - Forkhead box O1 (FOXO1)...
BioCentury | Dec 19, 2018
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting the BRD4-FOXO3-CDK6 axis could help treat luminal breast cancer resistant to AKT inhibitors. In patients who had been treated for hormone receptor-positive luminal...
BioCentury | Nov 6, 2018
Distillery Techniques

Drug delivery

...MALAT1) or forkhead box O1 (FOXO1) decreased levels of MALAT1 or FOXO1 mRNA compared with unconjugated MALAT1 or FOXO1...
...conjugate decreased FOXO1 mRNA and protein levels in pancreatic β islets compared with the unconjugated FOXO1...
BioCentury | Jul 25, 2018
Distillery Techniques

Disease models

...TECHNOLOGY: Transgenics and knockouts Zebrafish expressing human PAX3 and FOXO1 could be used to screen therapies...
...to screen therapies for rhabdomyosarcoma. Zebrafish harboring M214K-mutant p53, engineered to express human PAX3 and FOXO1...
...using the model to screen therapies. DESCRIPTION: Zebrafish expressing human paired box 3 (PAX3) and forkhead box O1 (FOXO1)...
BioCentury | Jul 11, 2018
Translation in Brief

The RNA Renaissance continues

...miR-96). The miRNA “acts as a dimmer switch” to diminish levels of pro-apoptotic transcription factor forkhead box O1 (FOXO1)...
...RNA,” Disney said. In a human triple-negative breast cancer (TNBC) cell line, the conjugate elevated FOXO1...
...about twofold and increased cell apoptosis. It showed a high selectivity for miR-96 over other FOXO1-targeting...
BioCentury | Jun 5, 2018
Distillery Therapeutics

Cancer

...TNBC cell line, the compound increased apoptosis and levels of miR-96’s target, pro-apoptotic transcription factor FOXO1...
...treatment. Next steps include evaluating the small molecule in animal disease models. TARGET/MARKER/PATHWAY: MicroRNA-96 (miR-96); forkhead box O1 (FOXO1)...
...CONTACT: Matthew D. Disney, The Scripps Research Institute, Jupiter, Fla. email: Disney@scripps.edu Jennie Walters The Scripps Research Institute Forkhead box O1 (FOXO1) MicroRNA-96...
BioCentury | Dec 18, 2017
Preclinical News

IL-18 secreting CAR T cells enhance immune killing of tumors

...a T cell expression signature of high T-box21 (Tbet; TBX21) and low forkhead box 01 (FOXO1...
...PD-1 expression than mice treated with unmodified CAR T cells. Elizabeth S. Eaton Torque Therapeutics Inc. University of Cologne Forkhead box O1 (FOXO1) Interleukin-12...
BioCentury | Nov 30, 2017
Translation in Brief

Two faces of FOXO1

...Columbia University and AstraZeneca plc (LSE:AZN; NYSE:AZN) have identified the first FOXO1 inhibitors that can selectively...
...in the liver they also trigger lipogenesis. Both those effects result from insulin’s inhibition of forkhead box O1 (FOXO1)...
...IMED) Biotech Unit to develop a HEK cell screen for FOXO1 inhibitors that would spare FOXO1-SIN3A...
BioCentury | Nov 1, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: October 2017

New Therapeutic Targets and Biomarkers: October 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October 2017. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Oct 26, 2017
Translation in Brief

Transient nanotargeting

...which are important for successful engraftment and outcomes of CAR T cell therapies, by carrying forkhead box O1 (FOXO1)...
...mRNA nanocarriers." Nature (2017) Winnie Pong, Staff Writer Fred Hutchinson Cancer Research Center University of Freiburg CD28 receptor CD3 Endoglin (CD105) (ENG) Forkhead box O1 (FOXO1) L...
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