...Cancer INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting USP21 or its substrate FOXM1...
...FOXM1 decreased proliferation compared with a non-targeting control siRNA, and the siRNAs targeting USP21 or FOXM1...
...FOXM1 inhibitors and testing them in animal models. TARGET/MARKER/PATHWAY: Ubiquitin specific peptidase 21 (USP21); Forkhead box M1 (FOXM1...

...INDICATION: Asthma In vitro and mouse studies identified a pyridine-based inhibitor of FOXM1 that could help...
...Screening of a small molecule library in cell-based assays identified a cyanodithienopyridine analog that inhibited FOXM1...
...Next steps include optimizing and testing the compound in other models of asthma. TARGET/MARKER/PATHWAY: Forkhead box M1 (FOXM1...

...FOXM1 could help treat cardiomyopathy. In patient samples of cardiac tissue, levels of SMARCA4 and FOXM1...
...of cardiac function compared with normal SMARCA4 or FOXM1 expression. Also in the model, a FOXM1...
...matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4; BRG1 ); forkhead box M1 (FOXM1...

...sample and mouse studies suggest FOXM1 inhibitors could help treat precursor B cell ALL (B-ALL). FOXM1...
...patient B-ALL cells, a peptide inhibitor of FOXM1 or thiostrepton - an antibiotic that inhibits FOXM1...
...molecule FOXM1 inhibitors and investigating the role of FOXM1 in B cell lymphoma. TARGET/MARKER/PATHWAY: Forkhead box M1 (FOXM1...

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Forkhead box M1 (FOXM1) In vitro...
...proliferation of breast cancer cell lines, bound to an isoform of the oncogenic transcription factor FOXM1...
...Kd of 10 mM. In a breast cancer cell line, thiostrepton inhibited the binding of FOXM1...