15:59 , Apr 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Inflammation

INDICATION: Asthma In vitro and mouse studies identified a pyridine-based inhibitor of FOXM1 that could help treat asthma. Screening of a small molecule library in cell-based assays identified a cyanodithienopyridine analog that inhibited FOXM1 with an...
07:00 , Sep 22, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4; BRG1); forkhead box M1 (FOXM1)

Cardiovascular disease INDICATION: Cardiomyopathy Patient sample and mouse studies suggest inhibiting SMARCA4 or FOXM1 could help treat cardiomyopathy. In patient samples of cardiac tissue, levels of SMARCA4 and FOXM1 were higher than in samples from healthy volunteers....
07:00 , Jul 23, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Bioinformatics platform for identifying tumor-specific RNA isoforms as therapeutic targets and/or markers in cancer

Biomarkersforkhead box M1FOXM1CD9University of California San Diego...
07:00 , Apr 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Forkhead box M1 (FOXM1)

Cancer INDICATION: Acute lymphoblastic leukemia (ALL) Patient sample and mouse studies suggest FOXM1 inhibitors could help treat precursor B cell ALL (B-ALL). FOXM1 transcript levels were higher in B-ALL cells from patients than in mature and precursor...
07:00 , Sep 15, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Forkhead box M1 (FOXM1) In vitro studies suggest thiostrepton or its analogs could help treat...