BioCentury | May 19, 2016
Distillery Therapeutics

Therapeutics: MAP kinase 7 (MAPK7; BMK1; ERK-5); mitogen-activated protein kinase kinase kinase 2 (MAP3K2); WNK lysine deficient protein kinase 1 (WNK1; PPP1R16

...prostate adenocarcinoma cancer harboring gain-of-function FOXF1 mutations. In tissue samples from patients with prostate adenocarcinoma, FOXF1...
...levels of FOXF1 correlated with high tumor levels of WNK1 and MAP3K2. In a human FOXF1-mutant...
...decreased proliferation, migration and invasion compared with vehicle. In an orthotopic xenograft mouse model of FOXF1-mutant...
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