02:24 , Mar 29, 2019 |  BC Innovations  |  Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
07:00 , Oct 11, 2012 |  BC Innovations  |  Cover Story

Ember: warming up to brown fat

A team led by Boston-area researchers has shown that inhibiting a cation channel dubbed TRPV4 induced white fat cells to behave like brown fat, thereby protecting mice from diet-induced obesity and insulin resistance. 1 Ember...
07:00 , May 28, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Lymphoedema Forkhead box C2 (FOXC2; MFH-1); nuclear factor of activated T cells cytoplasmic calcineurin-dependent 1 (NFATc1) Studies in mice...
01:24 , Jun 16, 2007 |  BC Extra  |  Clinical News

FOXC2 plays role in metastases

Researchers from the Whitehead Institute for Biomedical Research and colleagues reported in the Proceedings of the National Academy of Sciences that expression of the transcription factor forkhead box C2 (FOXC2) (MFH-1) is required for murine...