BioCentury | Apr 15, 2019
Distillery Therapeutics

Inhibiting NOX2 or FOXC1 to treat AML and CML

DISEASE CATEGORY: Cancer INDICATION: Acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML) Cell culture and mouse studies suggest inhibiting NOX2 or its downstream mediator FOXC1 could help treat AML and CML. In AML cells from...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...processes. Four abstracts feature the transcription factor FOXC2, which controls migration and epithelial-to-mesenchymal transition (EMT). FOXC2...
...No. 4669 ) is shown to decrease tumor invasion or stemness, respectively, in a FOXC2-dependent...
...protein 4 DEPDC5 - DEP domain containing 5 DHFR - Dihydrofolate reductase FOXC2 (MFH-1) - Forkhead box C2...
BioCentury | Aug 1, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: July 2018

New Therapeutic Targets and Biomarkers: July 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Jul 17, 2018
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting EZH2 or promoting FOXC1 expression could help treat the luminal B subtype of metastatic breast cancer. In patients with luminal B-type breast cancer,...
BioCentury | Oct 11, 2012
Cover Story

Ember: warming up to brown fat

...compounds that activate PR domain containing 16 ( PRDM16 ) and forkhead box C2 ( FOXC2 ; MFH-1...
BioCentury | May 28, 2009
Distillery Therapeutics

Indication: Cardiovascular disease

...Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Lymphoedema Forkhead box C2 (FOXC2; MFH-1...
...1 (NFATc1) Studies in mice and in cell culture suggest that agonizing the transcription factors FOXC2...
...be useful for treating lymphoedema, a lymphatic disorder associated with cancer surgery. In mice lacking Foxc2...
BioCentury | Jun 16, 2007
Clinical News

FOXC2 plays role in metastases

...forkhead box C2 (FOXC2) (MFH-1) is required for murine mammary carcinoma cells to reach full metastatic potential. FOXC2...
...was significantly overexpressed in tissue samples of human basal-like breast cancers. The authors suggested that FOXC2...
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