07:00 , Oct 15, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Glycinamide ribonucleotide formyltransferase (GARFT); folate receptor 1 (FOLR1; FR-α); FOLR2 (FR-β); solute carrier family 46 folate transporter m

Cancer INDICATION: Cancer Mouse and cell studies identified an inhibitor of GARFT , FOLR1 , FOLR2 and SLC46A1 that could help treat folate receptor-expressing cancers. Chemical synthesis and in vitro testing of pyrimidine antifolate thienoyl...
07:00 , May 7, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Folate receptor 1 (FOLR1; FR-a); FOLR2 (FR-b) A study in cell culture identified thieno[2,3-d] pyrimidine-based antifolate compounds that could help...