18:25 , Jun 28, 2018 |  BC Innovations  |  Translation in Brief

Synchronous signaling

As researchers explore next-generation CARs in cancer, one strategy is to tinker with the receptors’ modular components. A...
23:09 , Aug 28, 2017 |  BC Week In Review  |  Clinical News

Genentech reports preclinical data for p300/CBP inhibitor in prostate cancer

Researchers at the Genentech Inc. unit of Roche (SIX:ROG; OTCQX:RHHBY) reported preclinical data showing that prostate cancer candidate GNE-049 blocked expression of key proliferative genes and reduced tumor growth. In patient-derived xenograft mouse models of...
23:53 , Aug 23, 2017 |  BC Extra  |  Preclinical News

Genentech reports preclinical data for p300/CBP inhibitor in prostate cancer

Preclinical evidence supporting dual inhibition of E1A binding protein p300 (EP300; p300) and CREB binding protein ( CREBBP ; CBP) as an epigenetic strategy for treating prostate cancer is mounting. In a paper published in...
07:00 , Jul 23, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: FK506 binding protein 5 (FKBP5)

Neurology INDICATION: Anxiety Mouse studies suggest FKBP5 inhibitors could help treat anxiety. In mice, viral vector-mediated overexpression of FKBP5 in the basolateral or central amygdala increased anxiety-related behaviors compared with an empty vector. In a...
07:00 , Apr 28, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Anxiety EPH receptor B2 (EPHB2); FK506 binding protein 5 (FKBP5) Studies in mice suggest that inhibiting EPHB2 or FKBP5 could help...
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Techniques

Technology: Assays & screens

This week in techniques Approach Summary Licensing status Publication and contact information Assays & screens High throughput screening for glucocorticoid receptor (NR3C1; GCCR) modulators A high throughput fluorescent screening method to monitor the effects of...