08:00 , Feb 18, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: FK506 binding protein 4 (FKBP4)

Neurology INDICATION: Pain Mouse studies suggest inhibiting FKBP4 could help treat chronic pain. In two mouse models of chronic inflammatory pain and one model of chronic neuropathic pain, FKBP4 knockout decreased mechanical allodynia compared with...
07:00 , Jul 21, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Androgen receptor; FK506 binding protein 4 (FKBP4); prostate-specific antigen (KLK3; PSA) Cell culture studies identified compounds that block FKBP4-androgen receptor interactions and could...
08:00 , Feb 19, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Muscular dystrophy Ryanodine receptor 1 (RYR1); FK506 binding protein 4 (FKBP1A; calstabin-1) Studies in mice suggest that stabilizing the...