21:49 , Aug 29, 2018 |  BC Extra  |  Preclinical News

Sequential therapies trigger axon regeneration in spinal cord injury

University of California Los Angeles and Swiss Federal Institute of Technology Lausanne (EPFL) researchers showed delivery of three sequential therapies could trigger axon growth after complete spinal cord injury in rodents, suggesting the combination approach...
18:29 , May 15, 2018 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains Tannic acid conjugates of therapeutic proteins or viral particles could be used for cardiac-specific delivery of therapies for myocardial infarction (MI) and other heart diseases. The method involves conjugating therapeutic proteins or...
16:10 , Jun 7, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models iPS cell-derived brain microvascular endothelial cells could serve as BBB models for HD or Allan-Herndon-Dudley syndrome. The cells were generated by co-culturing iPS cells derived from patients in endothelial cell-conditioned media with...
20:34 , Jun 1, 2017 |  BC Innovations  |  Tools & Techniques

WuXi ex machina

Since its acquisition two years ago by New WuXi Life Science Ltd. , WuXi NextCode Genomics Inc. has been busy building out its artificial intelligence (AI) capabilities and test driving them via its expanding network...
16:31 , May 31, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: 3-D models hPSC-derived inner ear organoids with functional hair cells could be used to screen therapies for inner ear diseases. The organoids were generated from human embryonic stem cells (hESCs) or induced pluripotent stem...
01:05 , Apr 21, 2017 |  BC Innovations  |  Product R&D

Making marks at AACR

Biomarkers that could stratify patients, point to treatment combinations or predict toxicity were a major part of the conversation at this year’s AACR conference, where they emerged as potential difference makers for a range of...
14:16 , Apr 18, 2017 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Cell models A method for differentiating hPSCs into specific cell types by expressing select transcription factors could aid the development of cell-based disease models. The method involved engineering hPSCs via CRISPR-associated protein 9 (Cas9)-guided...
07:00 , Oct 26, 2015 |  BioCentury  |  Strategy

Collaborating on combos

As oncologists and drug developers converge on the idea that combination therapies built on a backbone of PD-L1 or PD-1 inhibitors could lead to cures for some cancers, or keep them at bay for years,...
07:00 , May 21, 2015 |  BC Innovations  |  Tools & Techniques

More than pluripotent

A group at the Salk Institute for Biological Studies has developed a method for generating pluripotent stem cells that solves the stability and scale-up problems of the commonly used approach, and results in a new...
08:00 , Dec 15, 2014 |  BioCentury  |  Strategy

Momenta moving on

Data announced in October represent the first fruits of Momenta Pharmaceuticals Inc. 's novel drug pipeline, which will play a larger role in the company's strategy going forward as it steps back from complex generics....