BioCentury | Feb 18, 2020
Regulation

Regulatory Roundup: PharmaMar-Jazz, BioCryst products under FDA review; plus EU approvals of Vyndaqel, Beovu; and more

...with cardiomyopathy. It had already been approved in Europe to treat TTR familial amyloid polyneuropathy (FAP...
BioCentury | Jan 25, 2020
Targets & Mechanisms

CAR T strategies for cracking the code in solid tumors

...factor receptor (EGFR) (ErbB1) (HER1) Epidermal growth factor receptor variant III (EGFRvIII) Enhancer of zeste homolog 2 (EZH2) Fibroblast activation protein (FAP) Folate...
BioCentury | Jan 24, 2020
Preclinical News

Jan. 23 Preclinical Quick Takes: Metastasis-associated cancer-associated fibroblast populations; plus NIH-TeneoBio and Basilea

...four subpopulations of cancer-associated fibroblasts (CAFs). Two subsets -- one positive and one negative for FAP...
...Integrin β(1); CXCL12 (SDF-1) - Chemokine CXC motif ligand 12; FAP (FAPA; FAPα) - Fibroblast activation protein...
BioCentury | Oct 11, 2019
Targets & Mechanisms

CAR Ts can move well beyond cancer, but will need to go allogeneic first

...FAP, a protein specifically expressed on the surface of fibroblasts responsible for cardiac fibrosis. The FAP-CAR...
...and expanding into more prevalent diseases,” said Gladstone. Targets DSG3 - Desmoglein 3 FAP - Fibroblast activation protein...
BioCentury | Jul 11, 2019
Targets & Mechanisms

The tumor stroma rises as the newest source of immuno-oncology targets

...anti-FAP-CD3 bispecific that directs T cells to kill tumor fibroblasts expressing the cell surface glycoprotein FAP...
...the tumor. The biotech’s MP0310 uses its DARPin technology to combine a localizer that targets FAP...
...CXCL10 (IP-10) - Chemokine CXC motif ligand 10 DKK1 - Dickkopf homolog 1 FAP - Fibroblast activation protein...
BioCentury | Jun 27, 2019
Distillery Therapeutics

4-1BBL fusion protein boosts T cell bispecific Abs for gastric cancer and lymphoma

...region of human IgG1 for enhanced serum stability, and a Fab fragment against CD19 or FAP...
...B cells or tumor stroma, respectively. In a xenograft mouse model of gastric cancer, the FAP-targeted...
BioCentury | Jun 22, 2019
Clinical News

June 21 Clinical Quick Takes: Melanoma miss for Exelixis/Genentech combo; plus Progenics, Turning Point, Gracell

...in May (see "Turning Point Sinks on ASCO Update" ). CPP to pursue approval of FAP...
...to slow progression to any FAP-related event, the primary endpoint in the Phase III CPP FAP-310...
BioCentury | May 6, 2019
Company News

Pfizer's small molecule tafamidis approved for TTR amyloid cardiomyopathy

...Vyndaqel was first approved in the EU in 2011 to treat TTR familial amyloid polyneuropathy (FAP...
BioCentury | Apr 6, 2019
Finance

Big caps under pressure

...Mallinckrodt plc (NYSE:MNK) / Zeria Pharmaceutical Co. Ltd. (Tokyo:4559) Eflornithine/ sulindac Treat familial adenomatous polyposis (FAP...
BioCentury | Mar 1, 2019
Financial News

Syncona leads CHF35M A round for Anaveon

...Phase I or II testing for a slew of other solid tumors. Roche’s RG7461, a FAP-targeted...
...Venture Fund's Florian Muellershausen. Syncona's Alice Renard will join as an observer. Targets: FAP - Fibroblast activation protein...
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