BioCentury | Nov 14, 2017
Distillery Therapeutics

Endocrine / Metabolic

...FBN1 preprotein cleavage product asprosin could help treat neonatal progeroid syndrome, which is caused by FBN1...
...intake compared with a control protein. In a mouse model of obesity, knock-in of a FBN1...
...which could not generate asprosin decreased body weight and increased glucose tolerance compared with wild-type FBN1...
BioCentury | Nov 14, 2013
Tools & Techniques

Scleroderma models: skin in the game

...American team has shown that mice harboring a mutant form of the glycoprotein fibrillin 1 ( Fbn1...
...GPIIIa ; CD61 ). In the Fbn1 -mutant mice, a mouse Cd29-activating antibody-which mimicked Fbn1's...
...al. has elucidated potential mechanisms by which mutations in the integrin-binding domain of fibrillin 1 ( Fbn1...
BioCentury | Nov 7, 2013
Distillery Techniques

Technology: Disease models

...models Fibrillin 1 (Fbn1)-mutant mouse models of systemic scleroderma Mice harboring mutations in the integrin-binding domain of Fbn1...
BioCentury | Apr 28, 2011
Targets & Mechanisms

MAPping out aneurysm

...to 1 in 5,000 people and is caused by a mutation in the fibrillin 1 ( FBN1...
...kinase pathway to treat cancer and autoimmune disease. Dietz's team characterized mice with mutations in Fbn1...
BioCentury | Mar 25, 2010
Distillery Therapeutics

Indication: Autoimmune disease

...In four families with stiff skin syndrome, fibrillin 1 (FBN1) mutations correlated with disease and individuals with FBN1...
...TGFB activity than healthy controls. Next steps include making transgenic mice that carry the disease-linked FBN1...
BioCentury | Oct 26, 2009
Finance

Ebb & Flow

Despite the brutal fundraising environment, New Enterprise Associates is close to wrapping up its 13th fund. According to an SEC filing, the firm has raised $2.46 billion of a planned $2.5 billion, which would put...
BioCentury | Aug 21, 2008
Cover Story

Stressing Out Over miRNA

Two papers, one published in the Proceedings of the National Academy of Sciences 1 and the other in Nature Immunology , 2 identify several microRNAs that play a role in cellular stress triggered by myocardial infarction...
BioCentury | Apr 3, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker /pathway Summary Licensing status Publication and contact information Cancer Metastatic breast cancer Netrin-1 A study in mice and human tumor samples suggests that inhibiting netrin-1 could be useful for...
BioCentury | Oct 6, 1997
Company News

Mount Sinai School of Medicine other research news

University researchers published the ability of mice with a mutation in the gene that is altered in Marfan syndrome to mimic the human disease. As reported in Nature Genetics, mice created with gene targeting to...
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