20:55 , Jul 27, 2017 |  BC Innovations  |  Translation in Brief

Sepsis' sweet tooth

It has long been known that pathogens rely on their host to provide metabolites and metals like iron to support growth and infections. Now, scientists from the Gulbenkian Institute of Science have shown how iron...
21:04 , Jul 18, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Sepsis Mouse studies suggest ferritin or promoting FTH1 expression could help treat sepsis. In a mouse model of cecal ligation and puncture (CLP)-induced sepsis, adenoviral-mediated overexpression of FTH1 in the liver or IV injection...
07:00 , Aug 27, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Ferritin heavy polypeptide 1 (FTH1); interleukin-1 (IL-1) β

Neurology INDICATION: Neurology Studies in cells and rats suggest inhibiting FTH1 or IL-1β could help treat HIV-associated neurocognitive disorders. FTH1 levels were higher and dendritic spine density was lower in the brains of rat models...
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Nerve damage Chemokine (CXC motif) receptor 4 (CXCR4; NPY3R); ferritin, heavy polypeptide 1 (FTH1; FHC) A study in rats suggests...
08:00 , Jan 29, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Cancer; diabetic retinopathy Ferritin, heavy polypeptide 1 (FTH1); cleaved high molecular weight kininogen (HKa) Studies in cell culture and in mice...