20:55 , Jul 11, 2019 |  BC Innovations  |  Distillery Therapeutics

FTO new target for melanoma

DISEASE CATEGORY: Cancer INDICATION: Melanoma Inhibiting FTO could treat melanoma and reduce resistance of the cancer cells to anti-PD-1 treatment. The protein's levels were higher in six total human and mouse melanoma cell lines, including...
12:57 , Apr 30, 2019 |  BC Innovations  |  Distillery Therapeutics

The Parkinson's drug Comtam for obesity and diabetes

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Obesity; diabetes In silico and mouse studies identified Comtan entacapone as an FTO inhibitor that could help treat obesity and diabetes. An in silico screen of FDA-approved drugs for FTO binding...
12:56 , Apr 30, 2019 |  BC Innovations  |  Distillery Therapeutics

Small molecule FTO inhibitor to treat AML

DISEASE CATEGORY: Cancer INDICATION: Acute myelogenous leukemia (AML) Cell culture and mouse studies identified a benzohydroxamic acid-based FTO inhibitor that could help treat AML. Chemical synthesis and optimization of meclofenamic acid, a previously reported FTO...
20:03 , Apr 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest inhibiting FTO or promoting METTL3 expression could help treat glioblastoma multiforme (GBM). In primary GBM stem cell-based assays of tumor formation, overexpression of METTL3 decreased growth...
20:03 , Apr 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest inhibiting FTO or promoting METTL3 expression could help treat glioblastoma multiforme (GBM). In primary GBM stem cell-based assays of tumor formation, overexpression of METTL3 decreased growth...
07:00 , Oct 8, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Co-crystal structure of fat mass and obesity associated (FTO) bound to an inhibitor

Drug platforms TECHNOLOGY: Crystal structures The co-crystal structure of human FTO bound to an inhibitor could aid the design of FTO inhibitors to treat obesity. A screen of benzenediol derivatives in an FTO inhibition assay...
07:00 , Apr 24, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Obesity Iroquois homeobox 3 (IRX3) In vitro and mouse studies suggest decreasing IRX3 expression could help treat obesity. In mice, sequencing and circular chromosome...
07:00 , Apr 15, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Endocrine disease Obesity Fat mass and obesity associated (FTO) X-ray crystallization studies determined the structure of human FTO, which could be useful for developing inhibitors...
07:00 , Sep 3, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity Fat mass and obesity associated (FTO) Studies in mice suggest that inhibiting FTO could help treat obesity. Mice with reduced FTO function had...
07:00 , May 22, 2008 |  BC Innovations  |  Targets & Mechanisms

Courting Melanocortin

A pair of genome-wide association studies makes the case that mutations near the melanocortin 4 receptor locus are common determinants of obesity in humans. 1,2 The studies may encourage discovery efforts in the obesity space...