...toxicity (DILI) Mouse studies suggest CPS1 could help treat DILI. In a mouse model of FASL-induced...
...recombinant CPS1 in larger animal models of liver injury. TARGET/MARKER/PATHWAY: Carbamoyl-phosphate synthase 1 (CPS1); Fas ligand (TNF superfamily, member 6) (FASL...

...DISEASE CATEGORY: Neurology INDICATION: Stroke Mouse studies suggest inhibiting FASL could help treat ischemic stroke. In...
...has PC111, a human mAb against FASL, in preclinical testing for pemphigus vulgaris. TARGET/MARKER/PATHWAY: Fas ligand (TNF superfamily, member 6) (FASL...
...doi:10.1073/pnas.1814394116 CONTACT: Yun Xu, Medical School of Nanjing University, Nanjing, China email: xuyun20042001@aliyun.com Claire Quang Nanjing University Fas ligand (TNF superfamily, member 6) (FASL) Stroke...

...INDICATION: Melanoma Mouse studies suggest FASL inhibitors could help treat immunotherapy-resistant melanoma. In a mouse model...
...a mAb against FASL, in preclinical development to treat pemphigus. TARGET/MARKER/PATHWAY: Fas receptor (CD95); Fas ligand (TNF superfamily, member 6) (FASL...
...Eynde, Ludwig Institute for Cancer Research, Brussels, Belgium email: benoit.vandeneynde@bru.licr.org Alicia Parker Ludwig Maximilians University of Munich Fas ligand (TNF superfamily, member 6) (FASL) Melanoma...

...at the Ludwig Institute for Cancer Research and colleagues identified Fas ligand (TNF superfamily, member 6; FASL...
...4 were apoptotic. The researchers observed high levels of interferon (IFN) gamma and expression of FASL...
...FASL is a viable strategy for improving cancer immunotherapy. Alicia Parker Ludwig Institute for Cancer Research Ltd. Fas ligand (TNF superfamily, member 6) (FASL) Interferon...

...first cohort of the open-label, Israeli Phase I/II ApoGraft01 trial evaluating transplanted ApoGraft exposed to FASL...
...a hematological malignancy to receive transplanted ApoGraft exposed to 10, 25, 50 or 100 ng/mL FASL...
...cells (MPBC) for stem cell transplantation that are exposed to Fas ligand (TNF superfamily, member 6; FASL...

...Phase I/II trial to evaluate transplanted ApoGraft exposed to 10, 25, 50 or 100 ng/mL FASL...
...cells (MPBC) for stem cell transplantation that are exposed to Fas ligand (TNF superfamily, member 6; FASL...

...cells (MPBC) for stem cell transplantation, which are exposed to Fas ligand (TNF superfamily, member 6; FASL...

...the mechanism involves "a non-canonical pathway" in which FASL engages the Fas receptor . Although FASL...
...Protein kinase B CD62L (SELL) - L selectin FASL (TNF superfamily, member 6) - Fas ligand...
...targeting NY-ESO-1 to treat melanoma. (2a) Pharmacological blockade of FASL. Anti-FASL mAbs (red) could prevent FASL...

...Cancer INDICATION: Cancer Cell culture and mouse studies suggest inhibiting FASL could help improve the efficacy...
...in naïve T cells cultured alone. In the T cell co-culture, a mAb targeting mouse FASL...
...Next steps include identifying anti-FASL mAbs that inhibit the process in human T cells. TARGET/MARKER/PATHWAY: Fas ligand (TNF superfamily, member 6)(FASL...

...Cancer Cancer Fas ligand (TNF superfamily, member 6; FASL); VEGF-A; cyclooxygenase (COX) Mouse studies suggest inhibiting FASL...
...Fasl expression in tumor vasculature compared with no treatment. In tumor-bearing mice, pretreatment with an anti-Fasl...