BioCentury | Apr 15, 2019
Distillery Therapeutics

CPS1 protein to treat drug-induced liver toxicity

...toxicity (DILI) Mouse studies suggest CPS1 could help treat DILI. In a mouse model of FASL-induced...
...recombinant CPS1 in larger animal models of liver injury. TARGET/MARKER/PATHWAY: Carbamoyl-phosphate synthase 1 (CPS1); Fas ligand (TNF superfamily, member 6) (FASL...
BioCentury | Mar 19, 2019
Distillery Therapeutics

Inhibiting FASL for ischemic stroke

...DISEASE CATEGORY: Neurology INDICATION: Stroke Mouse studies suggest inhibiting FASL could help treat ischemic stroke. In...
...has PC111, a human mAb against FASL, in preclinical testing for pemphigus vulgaris. TARGET/MARKER/PATHWAY: Fas ligand (TNF superfamily, member 6) (FASL...
...doi:10.1073/pnas.1814394116 CONTACT: Yun Xu, Medical School of Nanjing University, Nanjing, China email: xuyun20042001@aliyun.com Claire Quang Nanjing University Fas ligand (TNF superfamily, member 6) (FASL) Stroke...
BioCentury | Dec 13, 2017
Distillery Therapeutics

Cancer

...INDICATION: Melanoma Mouse studies suggest FASL inhibitors could help treat immunotherapy-resistant melanoma. In a mouse model...
...a mAb against FASL, in preclinical development to treat pemphigus. TARGET/MARKER/PATHWAY: Fas receptor (CD95); Fas ligand (TNF superfamily, member 6) (FASL...
...Eynde, Ludwig Institute for Cancer Research, Brussels, Belgium email: benoit.vandeneynde@bru.licr.org Alicia Parker Ludwig Maximilians University of Munich Fas ligand (TNF superfamily, member 6) (FASL) Melanoma...
BioCentury | Nov 16, 2017
Preclinical News

FAS/FASL pathway involved in immunotherapy resistance

...at the Ludwig Institute for Cancer Research and colleagues identified Fas ligand (TNF superfamily, member 6; FASL...
...4 were apoptotic. The researchers observed high levels of interferon (IFN) gamma and expression of FASL...
...FASL is a viable strategy for improving cancer immunotherapy. Alicia Parker Ludwig Institute for Cancer Research Ltd. Fas ligand (TNF superfamily, member 6) (FASL) Interferon...
BioCentury | Apr 20, 2017
Clinical News

ApoGraft: Ph I/II ApoGraft01 ongoing

...first cohort of the open-label, Israeli Phase I/II ApoGraft01 trial evaluating transplanted ApoGraft exposed to FASL...
...a hematological malignancy to receive transplanted ApoGraft exposed to 10, 25, 50 or 100 ng/mL FASL...
...cells (MPBC) for stem cell transplantation that are exposed to Fas ligand (TNF superfamily, member 6; FASL...
BioCentury | Feb 9, 2017
Clinical News

ApoGraft: Ph I/II started

...Phase I/II trial to evaluate transplanted ApoGraft exposed to 10, 25, 50 or 100 ng/mL FASL...
...cells (MPBC) for stem cell transplantation that are exposed to Fas ligand (TNF superfamily, member 6; FASL...
BioCentury | Dec 2, 2016
Company News

Cellect, Hadassah deal

...cells (MPBC) for stem cell transplantation, which are exposed to Fas ligand (TNF superfamily, member 6; FASL...
BioCentury | Jan 28, 2016
Tools & Techniques

Peer pressure

...the mechanism involves "a non-canonical pathway" in which FASL engages the Fas receptor . Although FASL...
...Protein kinase B CD62L (SELL) - L selectin FASL (TNF superfamily, member 6) - Fas ligand...
...targeting NY-ESO-1 to treat melanoma. (2a) Pharmacological blockade of FASL. Anti-FASL mAbs (red) could prevent FASL...
BioCentury | Jan 21, 2016
Distillery Therapeutics

Therapeutics: Fas ligand (TNF superfamily, member 6)(FASL)

...Cancer INDICATION: Cancer Cell culture and mouse studies suggest inhibiting FASL could help improve the efficacy...
...in naïve T cells cultured alone. In the T cell co-culture, a mAb targeting mouse FASL...
...Next steps include identifying anti-FASL mAbs that inhibit the process in human T cells. TARGET/MARKER/PATHWAY: Fas ligand (TNF superfamily, member 6)(FASL...
BioCentury | Jun 5, 2014
Distillery Therapeutics

Indication: Cancer

...Cancer Cancer Fas ligand (TNF superfamily, member 6; FASL); VEGF-A; cyclooxygenase (COX) Mouse studies suggest inhibiting FASL...
...Fasl expression in tumor vasculature compared with no treatment. In tumor-bearing mice, pretreatment with an anti-Fasl...
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