BC Innovations | Mar 29, 2017
Distillery Therapeutics

Hepatic

INDICATION: Non-alcoholic steatohepatitis (NASH) Patient sample, mouse and non-human primate (NHP) studies suggest CFLAR or its mimics could help treat NASH. In liver tissue samples, levels of CFLAR were lower in patients than in healthy...
BC Extra | Feb 21, 2017
Clinical News

Chinese scientists identify NASH target

Researchers in China identified CASP8 and FADD like apoptosis regulator (CFLAR; c-FLIP) as a new target for non-alcoholic steatohepatitis (NASH) that could suppress the disease and related metabolic disorders. The study was published in Nature...
BC Innovations | Apr 28, 2016
Distillery Therapeutics

Therapeutics: Fas-associated via death domain (FADD); receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3)

Cancer INDICATION: Colorectal cancer Mouse studies suggest necroptotic cancer cells could help treat colon cancer. In a mouse colon carcinoma cell line, vector-mediated expression of FADD and RIPK3 increased necroptosis compared with no treatment. In...
BioCentury | Jul 30, 2007
Tools & Techniques

Caspase cascade

Caspase cascade By targeting procaspase-3 , BioLineRx Ltd. believes BL-4030 can bypass upstream elements in the intrinsic and extrinsic apoptosis pathways. In the intrinsic pathway, the mitochondrial membrane [1a] is depolarized due to cell stress, resulting...
BC Week In Review | Mar 18, 2002
Company News

University of California other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence that changes in cellular expression of the apoptosis-related proteins FLIP, FADD , and DAP3 correspond with death of CLL cells induced by treatment with...
BioCentury | Jan 8, 2001
Tools & Techniques

Driver of death-signaling

Daichii scientists last week described in Nature Medicine the identification of SADS (small accelerator of death-signaling), which is expressed in lung, liver, small intestine, lung and brain tissue. Fas is a transmembrane receptor that signals...
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