00:51 , Mar 29, 2017 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Non-alcoholic steatohepatitis (NASH) Patient sample, mouse and non-human primate (NHP) studies suggest CFLAR or its mimics could help treat NASH. In liver tissue samples, levels of CFLAR were lower in patients than in healthy...
23:41 , Feb 21, 2017 |  BC Extra  |  Clinical News

Chinese scientists identify NASH target

Researchers in China identified CASP8 and FADD like apoptosis regulator (CFLAR; c-FLIP) as a new target for non-alcoholic steatohepatitis (NASH) that could suppress the disease and related metabolic disorders. The study was published in Nature...
07:00 , Apr 28, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Fas-associated via death domain (FADD); receptor-interacting serine-threonine kinase 3 (RIPK3; RIP3)

Cancer INDICATION: Colorectal cancer Mouse studies suggest necroptotic cancer cells could help treat colon cancer. In a mouse colon carcinoma cell line, vector-mediated expression of FADD and RIPK3 increased necroptosis compared with no treatment. In...
07:00 , Jul 30, 2007 |  BioCentury  |  Tools & Techniques

Caspase cascade

Caspase cascade By targeting procaspase-3 , BioLineRx Ltd. believes BL-4030 can bypass upstream elements in the intrinsic and extrinsic apoptosis pathways. In the intrinsic pathway, the mitochondrial membrane [1a] is depolarized due to cell stress,...
08:00 , Mar 18, 2002 |  BC Week In Review  |  Company News

University of California other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence that changes in cellular expression of the apoptosis-related proteins FLIP, FADD , and DAP3 correspond with death of CLL cells induced by treatment...
08:00 , Jan 8, 2001 |  BioCentury  |  Tools & Techniques

Driver of death-signaling

Daichii scientists last week described in Nature Medicine the identification of SADS (small accelerator of death-signaling), which is expressed in lung, liver, small intestine, lung and brain tissue. Fas is a transmembrane receptor that signals...