16:15 , Oct 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Hematology

INDICATION: Anemia Cell culture and mouse studies suggest inhibiting SH2B3 could help treat FANCD2-deficient Fanconi anemia, a disorder involving loss of hematopoietic stem and progenitor cells (HSPCs). In FANCD2-deficient mouse HSPCs, SH2B3 knockout increased growth...
07:00 , Jun 11, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Anemia Fanconi anemia complementation group A (FANCA); FANCD2 Studies in human cells suggest that induced pluripotent stem (iPS) cells carrying wild-type...
08:00 , Jan 5, 2009 |  BC Week In Review  |  Clinical News

Biomarker Panels diagnostic data

Data from 115 evaluable patients with triple negative breast cancers enrolled in a U.S. trial showed that a panel of 4 DNA repair proteins (XPF, FANCD2 , MLH1 and MK2 ) met the primary endpoint...