BioCentury | Jun 25, 2019
Preclinical News

Alnylam preclinical data latest sign companies still plugging away at oral oligos

...serum levels of Factor XII, a coagulation factor expressed in the liver. Potency and duration of Factor XII...
BioCentury | Nov 30, 2016
Company News

Arrowhead prunes pipeline over toxicity concerns

...Anzalone said the company is "close" to choosing lead candidates in its subcutaneous programs targeting Factor XII...
BioCentury | Jun 2, 2016
Distillery Therapeutics

Therapeutics: Factor XII

...Autoimmune disease INDICATION: Multiple sclerosis (MS) Patient sample and mouse studies suggest inhibiting Factor XII could help...
...cord inflammation compared with normal Factor XII expression. In a mouse model of relapsing-remitting MS, a Factor XII...
...a siRNA targeting Factor XII, in preclinical testing to treat hereditary angioedema (HAE) and thrombosis. TARGET/MARKER/PATHWAY: Factor XII...
BioCentury | Nov 9, 2015
Company News

Dyax, Shire deal

...receptor transporter alpha ( FCGRT ; FCRN ), and DX-4012 is a mAb against activated Factor XII...
BioCentury | Nov 3, 2015
Top Story

Shire builds on HAE franchise with Dyax takeout

...receptor transporter alpha ( FCGRT ; FCRN ) and DX-4012 is a mAb against activated Factor XII...
BioCentury | Feb 27, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...factor XII Rabbit studies suggest antisense oligonucleotides (ASOs) that knock down expression of factor XI or factor XII...
...used to prevent contact-induced coagulation. In rabbits with a catheter, ASOs targeting factor XI or factor XII...
BioCentury | Feb 27, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...Publication and contact information Cardiovascular disease Blood coagulation Factor XII Mouse and rabbit studies suggest an anti-factor XII...
...An in vitro screen of a human Fab-based phage antibody library identified 3F7, which inhibited factor XII...
...Phase I trial in hereditary angioedema, which is associated with mutations in the gene encoding factor XII...
BioCentury | Feb 27, 2014
Targets & Mechanisms

The XII factor

...a feat. A group from Isis Pharmaceuticals Inc. and McMaster University obtained similar results with factor XII...
...maintains that blocking a downstream target, factor XI , is a better approach. Whether blocking factor XII...
...led by Jeffrey Weitz also identified factor XII as an anticoagulation target. The group showed that factor XII-directed...
BioCentury | Oct 15, 2009
Distillery Therapeutics

Indication: Cardiovascular disease

...Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Arterial thrombosis; venous thromboembolism (VTE) Factor XII...
...human plasma, a recombinant variant of Ir-CPI (Ixodes ricinus contact phase inhibitor) blocked activation of Factor XII...
BioCentury | Nov 10, 2008
Clinical News

Recombinant coagulation Factor XIII: Phase III started

...target: Fibrin Description: Recombinant Factor XIII (rh FXIII) Indication: Prevent bleeding in patients with congenital Factor XII...
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