BioCentury | Dec 5, 2017
Distillery Therapeutics

Hematology

...INDICATION: Hemophilia Cell culture and mouse studies suggest an engineered mutant Factor VIIa/Tissue Factor complex could help treat hemophilia...
...complex in additional models of hemophilia A. TARGET/MARKER/PATHWAY: Factor VIIa; tissue factor (TF; CD142; thromboplastin); Factor VIIa/Tissue Factor complex...
...2017 doi:10.1073/pnas.1618713114 CONTACT: Henrik Østergaard, Novo Nordisk A/S, Maaloev, Denmark email: hqsg@novonordisk.com Claire Quang Novo Nordisk A/S Factor VIIa Factor VIIa/Tissue Factor complex Tissue...
BioCentury | Jul 16, 2015
Translation in Brief

Bayer's replacement antibody

...plasmon resonance, the team showed that BAY 1093884 but not BAY 1093889 competed with the Factor VIIa/Tissue Factor complex...
...in the presence of TFPI, but only BAY1093884 also blocked the TFPI-dependent inhibition of the Factor VIIa/Tissue Factor complex...
BioCentury | Aug 28, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...Publication and contact information Cardiovascular disease Thrombosis Factor Xa; thrombin (factor IIa; F2); factor IXa; factor VIIa/tissue factor complex...
...thrombosis. In plasma and whole-blood clotting assays, pairs of RNA aptamers that inhibited factor IXa, factor VIIa/tissue factor complex...
BioCentury | Aug 6, 2007
Clinical News

rNAPc2: Development halted

...term proof-of-concept data. Nuvelo Inc. (NUVO), San Carlos, Calif. Product: rNAPc2 Business: Cancer Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Jun 25, 2007
Clinical News

rNAPc2: Phase II data

...Sept. 11, 2006). Nuvelo Inc. (NUVO), San Carlos, Calif. Product: rNAPc2 Business: Cardiovascular Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Jan 8, 2007
Clinical News

rNAPc2: Phase II started

...in 100 patients. Nuvelo Inc. (NUVO), San Carlos, Calif. Product: rNAPc2 Business: Cancer Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Sep 11, 2006
Clinical News

rNAPc2: Phase IIa data

...meeting in Barcelona. Nuvelo Inc. (NUVO), San Carlos, Calif. Product: rNAPc2 Business: Cardiovascular Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Sep 11, 2006
Clinical News

rNAPc2: Phase II data

...meeting in Barcelona. Nuvelo Inc. (NUVO), San Carlos, Calif. Product: rNAPc2 Business: Cardiovascular Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Nov 21, 2005
Clinical News

rNAPc2: Phase IIa data

...Association meeting in Dallas. Nuvelo Inc. (NUVO), Sunnyvale, Calif. Product: rNAPc2 Business: Cardiovascular Molecular target: Factor VIIa/Tissue Factor complex...
BioCentury | Aug 29, 2005
Clinical News

rNAPc2: Phase IIb started

...cohorts may be added. Nuvelo Inc. (NUVO), Sunnyvale, Calif. Product: rNAPc2 Business: Cardiovascular Molecular target: Factor VIIa/Tissue Factor complex...
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