FDA and EMA issued Letters of Support for four skeletal muscle biomarkers identified by the Predictive Safety Testing Consortium (PSTC) of the Critical Path Institute (C-Path). Elevated levels of myosin light chain 3 ( MYL3 ),...
Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Fatty acid binding protein 5 psoriasis-associated (FABP5; EFABP) In vitro and mouse studies suggest FABP5 inhibition could help treat breast cancer. In mouse...
...secretion of Fabp4 from adipocytes was greater than that in lean mice, and a neutralizing FABP4-targeting... ...from adipocytes was greater than that in lean mice, and a neutralizing FABP4-targeting antibody decreased Fabp4... ...and clearance compared with a control antibody. Next steps include developing a humanized mAb targeting FABP4...
Nanomix began a clinical trial to evaluate its Omega-3 Cardiac Panel in about 170 healthy volunteers. Nanomix Inc. , Emeryville, Calif. Product: Omega-3 Cardiac Panel Business: Diagnostic Molecular target: NA Description: Mobile in vitro diagnostic platform...
...and contact information Cancer Ovarian cancer Fatty acid binding protein 4 adipocyte (FABP4) Patient tissue and mouse studies suggest inhibiting FABP4... ...in the abdominal cavity composed primarily of adipocytes. In tumor tissue from ovarian cancer patients, FABP4... ...Fabp4 deficiency lowered metastases compared with no deficiency (p<0.001). Next steps include testing small molecule FABP4...
Randox launched an automated assay for heart-type fatty acid binding protein (H-FABP) worldwide to aid in the diagnosis and management of suspected acute coronary syndrome (ACS). The test has CE Mark approval in Europe. Randox...
This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Addiction; pain Fatty acid binding protein 5 brain (FABP5); FABP7 In vitro studies suggest that inhibiting FABPs could increase endocannabinoid...
Researchers published in the Proceedings of the National Academy of Sciences evidence that tau is required in the pathogenesis of AD-associated neurotoxicity. Mouse neurons expressing either mouse or human tau proteins degenerated after treatment with...
