BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...CD1D 6 0 Cyclin A2 (CCNA2) 4 0 DNA ligase 4 (LIG4) 4 0 Fatty acid binding protein 4 adipocyte (FABP4...
BioCentury | Apr 14, 2015
Politics & Policy

Regulators support C-Path's skeletal muscle biomarkers

FDA and EMA issued Letters of Support for four skeletal muscle biomarkers identified by the Predictive Safety Testing Consortium (PSTC) of the Critical Path Institute (C-Path). Elevated levels of myosin light chain 3 ( MYL3 ),...
BioCentury | Jul 11, 2013
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer Fatty acid binding protein 5 psoriasis-associated (FABP5; EFABP) In vitro and mouse studies suggest FABP5 inhibition could help treat breast cancer. In mouse...
BioCentury | Jun 6, 2013
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...secretion of Fabp4 from adipocytes was greater than that in lean mice, and a neutralizing FABP4-targeting...
...from adipocytes was greater than that in lean mice, and a neutralizing FABP4-targeting antibody decreased Fabp4...
...and clearance compared with a control antibody. Next steps include developing a humanized mAb targeting FABP4...
BioCentury | Feb 18, 2013
Clinical News

Omega-3 Cardiac Panel: Clinical trial started

Nanomix began a clinical trial to evaluate its Omega-3 Cardiac Panel in about 170 healthy volunteers. Nanomix Inc. , Emeryville, Calif. Product: Omega-3 Cardiac Panel Business: Diagnostic Molecular target: NA Description: Mobile in vitro diagnostic platform...
BioCentury | Nov 10, 2011
Distillery Therapeutics

Indication: Cancer

...and contact information Cancer Ovarian cancer Fatty acid binding protein 4 adipocyte (FABP4) Patient tissue and mouse studies suggest inhibiting FABP4... the abdominal cavity composed primarily of adipocytes. In tumor tissue from ovarian cancer patients, FABP4...
...Fabp4 deficiency lowered metastases compared with no deficiency (p<0.001). Next steps include testing small molecule FABP4...
BioCentury | Jun 27, 2011
Company News

Randox Laboratories Ltd. sales and marketing update

Randox launched an automated assay for heart-type fatty acid binding protein (H-FABP) worldwide to aid in the diagnosis and management of suspected acute coronary syndrome (ACS). The test has CE Mark approval in Europe. Randox...
BioCentury | Mar 26, 2009
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Addiction; pain Fatty acid binding protein 5 brain (FABP5); FABP7 In vitro studies suggest that inhibiting FABPs could increase endocannabinoid...
BioCentury | Jun 18, 2007
Clinical News

Bristol-Myers preclinical data

...insulin sensitivity and glucose metabolism vs. controls. BMS309403 inhibits adipocyte fatty-acid binding protein aP2 ( FABP4...
BioCentury | Apr 22, 2002
Company News

Cognosci Inc. other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence that tau is required in the pathogenesis of AD-associated neurotoxicity. Mouse neurons expressing either mouse or human tau proteins degenerated after treatment with...
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