23:44 , Jul 25, 2019 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: June 2019

New Therapeutic Targets and Biomarkers: June 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in June. Therapeutic targets are defined as any protein, gene or other molecule...
21:50 , Jun 11, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibiting FANCM-TOP3A-RMI1 interaction for osteosarcoma, Lesch-Nyhan syndrome

DISEASE CATEGORY: Cancer; endocrine/metabolic INDICATION: Bone cancer; metabolic Cell culture studies suggest inhibiting the FANCM-TOP3A-RMI1 interaction could help treat osteosarcoma and Lesch-Nyhan syndrome. In two human osteosarcoma cell lines and a human telomerase reverse transcriptase...
16:10 , Jul 24, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Cell culture and mouse studies suggest inhibiting RAD52 could help treat FANCM-deficient colorectal cancer. In a FANCM-knockout human colorectal cancer cell line, an shRNA targeting RAD52 encoded in a retroviral or lentiviral...