BC Innovations | Sep 26, 2018
Distillery Therapeutics

Neurology

INDICATION: Leukodystrophy Cell culture, worm and mouse studies suggest inhibiting HDAC6 and other HDACs could help treat Cockayne syndrome, a leukodystrophy caused by ERCC6 mutations that is associated with defects in autophagy, neurogenesis and neuronal...
BC Innovations | Mar 17, 2016
Distillery Therapeutics

Therapeutics: Brain-derived neurotrophic factor (BDNF); neurotrophic tyrosine kinase receptor 2 (TrkB; NTRK2); excision repair cross-complementation group 6 (ER

Neurology INDICATION: Leukodystrophy Patient sample and cell studies suggest BDNF , BDNF mimetics or other agonists of its receptor, TrkB , could help treat Cockayne syndrome, a leukodystrophy caused by ERCC6 mutations that is associated with defects...
BC Week In Review | Dec 23, 2013
Clinical News

TC-5619: Development discontinued

Targacept discontinued development of TC-5619 to treat negative symptoms and cognitive dysfunction in patients with schizophrenia after top-line data from a double-blind, international Phase IIb trial in 477 patients with schizophrenia showed that once-daily 5...
BC Week In Review | Jan 14, 2013
Clinical News

Aggrastat tirofiban regulatory update

Medicure submitted an sNDA to FDA to expand the label of Aggrastat tirofiban to include a high-dose regimen consisting of an initial bolus of 25 µg/kg Aggrastat and then continued at 0.15 µg/kg/min. The non-peptide...
BC Innovations | Mar 24, 2011
Tools & Techniques

Aspiring cancer diagnostic

Massachusetts researchers have developed portable NMR technology that uses fine needle aspirates to help scientists diagnose cancer more quickly and accurately than is possible with conventional tumor biopsies. 1 Although the technology could confirm the...
BC Week In Review | Oct 6, 2008
Company News

Cellumen, Alzheimer's Drug Discovery Foundation deal

Cellumen received undisclosed funding from the foundation to create a cellular model of Alzheimer's disease. Cellumen will use its Cellular Systems Biology (CSB) technology to develop a panel of assays and biosensors to determine target...
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