BioCentury | Dec 19, 2019

Targeting the integrated stress response to treat Down syndrome

...ISR modulators for cognitive decline. TARGET/MARKER/PATHWAY: Eukaryotic translation initiation factor 2 α kinase 2 (EIF2AK2); eukaryotic translation initiation factor 2B (EIF2B)...
...LLC Baylor College of Medicine University of California San Francisco Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) Eukaryotic translation initiation factor 2B (EIF2B)...
BioCentury | May 6, 2019
Translation in Brief

Baby brain organoids link stress response to hypoxic encephalopathy

...reported that ISRIB could help treat vanishing white matter disease (VWMD). Sandi Wong, Staff Writer Calico LLC Stanford University Eukaryotic translation initiation factor 2B (EIF2B) Encephalopathy brain...
BioCentury | May 2, 2018
Preclinical News

UCSF study suggests stress response inhibitor could treat prostate cancer

...researchers from Calico and AbbVie Inc. (NYSE:ABBV) published a paper in eLife suggesting that activating eukaryotic translation initiation factor 2B (EIF2B)...
...plans in prostate cancer. Elizabeth S. Eaton Calico LLC University of California San Francisco Eukaryotic translation initiation factor 2 alpha Eukaryotic translation initiation factor 2B (EIF2B) Phosphatase...
BioCentury | Apr 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: March 2018

...MAPT; FTDP-17) could help treat frontotemporal dementia. Salk Institute for Biological Studies Preclinical news Leukodystrophy Eukaryotic translation initiation factor 2B (EIF2B)...
BioCentury | Mar 7, 2018
Preclinical News

Calico team publishes on vanishing white matter disease

...Calico Life Sciences LLC (South San Francisco, Calif.) and AbbVie Inc. (NYSE:ABBV) suggested that activating eukaryotic translation initiation factor 2B (EIF2B)...
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