21:40 , Jul 12, 2017 |  BC Extra  |  Preclinical News

Paper identifies target for TBI-related cognitive defects

In a paper published in Proceedings of the National Academy of Sciences , researchers at the University of California San Francisco suggest inhibiting the integrated stress response (ISR) pathway could help treat cognitive deficits due...
18:00 , Feb 15, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Acute lymphoblastic leukemia (ALL) Cell culture and mouse studies suggest inhibition of eIF-2α could help treat T cell ALL. Comparative gene expression analyses of a mouse T cell ALL cell line treated with a...
07:00 , Apr 23, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Protein phosphatase 1 regulatory inhibitor subunit 15A (PPP1R15A; PEG-3); eukaryotic translation initiation factor 2 (eIF2) subunit 1α (eIF-2α; EI

Neurology INDICATION: Amyotrophic lateral sclerosis (ALS); neuropathy In vitro and mouse studies suggest a selective inhibitor of PPP1R15A - the regulatory subunit of eIF-2α - could help treat ALS, Charcot-Marie-Tooth disease and other diseases involving...
07:00 , Sep 4, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Cancer Caspase-12; eukaryotic translation initiation factor 2, subunit 1a (EIF2S1; EIF2a); protein kinase regulated by RNA (PKR) Studies in cell...