17:39 , Nov 15, 2016 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Malaria In vitro and mouse studies identified an EEF2 inhibitor that could help treat malaria. In cultured Plasmodium falciparum , a previously reported quinoline-4-carboxamide-based EEF2 inhibitor blocked growth of late-stage gametocytes and blood-stage parasites...
07:00 , Sep 29, 2016 |  BC Innovations  |  Targets & Mechanisms

Hitting for the cycle

Driven by the need for antimalarial drugs that hit all stages of the life cycle of the malaria parasite, a group at the Broad Institute of MIT and Harvard has constructed and screened a diverse...
07:00 , Jun 25, 2015 |  BC Innovations  |  Translation in Brief

One-stop malaria treatment

Researchers at the University of Dundee have identified a compound that not only has the potential to treat malaria as a single-dose treatment, but also could reduce transmission and provide chemoprotection against the malaria parasite...
07:00 , Jun 20, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Eukaryotic translation elongation factor 2 kinase (EEF2K) Patient, mouse and cell culture studies suggest inhibiting EEF2K could help improve the efficacy of nutrient deprivation...
07:00 , Sep 6, 2012 |  BC Innovations  |  Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...
07:00 , Jun 23, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Depression Eukaryotic translation elongation factor 2 kinase (EEF2K) Mouse studies suggest decreasing EEF2K activity could help treat depression. In mice, two different EEF2K inhibitors decreased...
08:00 , Feb 24, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Glioma Protein kinase B (PKB; Akt); eukaryotic translation elongation factor 2 (EEF2) In vitro and mouse studies suggest that inhibiting EEF2...