BioCentury | Aug 7, 2020
Deals

Billion-dollar Biogen deal gives Denali fuel to validate CNS delivery platform

...from Sangamo Therapeutics Inc. (NASDAQ:SGMO) (see “Biogen Expands its Modality Toolkit” ). Targets EIF2B -- Eukaryotic translation...
BioCentury | Jun 11, 2020
Deals

Prism’s peptide mimetic platform finds second discovery partner

...undisclosed CNS indication. Targets CTNNB1 - β-catenin CREBBP (CBP) - CREB binding protein eIF4EBP1 - Eukaryotic translation...
BioCentury | Apr 18, 2020
Finance

April 17 Quick Takes: Mabworks’ $160M series C; plus RDMD, PIC, SIRS, Atomo and Lantern

...II testing for prostate cancer, to Oncology Venture A/S (SSE:OV) in 2015. Targets eIF4E - Eukaryotic translation...
BioCentury | Mar 20, 2020
Translation in Brief

Vaxxas' temperature-stable, low-dose vaccine patch; plus Stanford screen for 3-D tumor targets, new invasion mechanism for SARS-CoV-2 and PharmaMar

...2 BSG (EMMPRIN; CD147) - Basigin Ok blood group CPD - carboxypeptidase D EEF1A2 - Eukaryotic translation...
...Gates Foundation PharmaMar S.A. Stanford University Influenza A virus hemagglutinin (Influenza A HA) Basigin Ok blood group (BSG) (EMMPRIN) (CD147) Eukaryotic translation...
BioCentury | Feb 27, 2020
Product Development

Amgen banks on speed to maintain edge in two hot cancer spaces

...  Targets BCMA (TNFRSF17; CD269) - Tumor necrosis factor receptor superfamily member 17 eIF4E - Eukaryotic translation...
BioCentury | Feb 26, 2020
Distillery Therapeutics

Boosting FGF21 signaling to treat pancreatitis

...89bio Inc. (NASDAQ:ETNB) is in Phase I/II for NASH. TARGET/MARKER/PATHWAY: Fibroblast growth factor 21 (FGF21); eukaryotic translation...
...same affiliation as above email: davo.mango@utsouthwestern.edu Claire Quang University of Texas Southwestern Medical Center Fibroblast growth factor 21 (FGF21) Eukaryotic translation...
BioCentury | Jan 9, 2020
Company News

Pfizer dips into translational regulation for cancer with eFFECTOR deal

...as a natural ligand competitor. Targets: eIF4E - Eukaryotic translation initiation factor 4E eIF4A1 (EIF4A) - Eukaryotic translation...
...Mammalian target of rapamycin PI3K (PI3K) - Phosphoinositide 3-kinase Lauren Martz, Senior Editor Effector Therapeutics Inc. Pfizer Inc. Eukaryotic translation...
BioCentury | Dec 19, 2019

Inhibiting the EIF4G1-EIF4E interaction to treat autism

...for B cell malignancies. TARGET/MARKER/PATHWAY: Cullin 3 (CUL3); Eukaryotic translation initiation factor 4 γ 1 (EIF4G1); eukaryotic translation...
...Reserve University, Cleveland, Ohio email: lin.mei@case.edu Claire Quang Case Western Reserve University Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) Eukaryotic translation...
BioCentury | Dec 19, 2019

Combined inhibition of EIF4A1 and glutaminase for pancreatic cancer

...Inc. has the EIF4A1 inhibitor zotatifin (eFT226) in Phase I/II testing for solid tumors. TARGET/MARKER/PATHWAY: Eukaryotic translation...
BioCentury | Dec 19, 2019

Targeting the integrated stress response to treat Down syndrome

...other ISR modulators for cognitive decline. TARGET/MARKER/PATHWAY: Eukaryotic translation initiation factor 2 α kinase 2 (EIF2AK2); eukaryotic translation...
...Sciences LLC Baylor College of Medicine University of California San Francisco Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) Eukaryotic translation...
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