19:02 , Nov 27, 2017 |  BC Innovations  |  Distillery Therapeutics

Renal

INDICATION: Renal damage Mouse studies suggest 14,15-epoxyeicosatrienoic acid (EET) or inhibition of its catabolic enzyme EPHX2 could help treat acute kidney injury (AKI). In a mouse model of AKI, 14,15-EET decreased kidney injury and increased survival...
07:00 , Sep 10, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Epoxyeicosatrienoic acid (EET)

Hematology INDICATION: Stem cell transplant Zebrafish and mouse studies suggest EETs could enhance engraftment of hematopoietic stem/progenitor cell (HSPC) transplants. Screening of a library of bioactive compounds in a zebrafish-based assay of HSPC engraftment identified two EETs...
08:00 , Jan 12, 2012 |  BC Innovations  |  Targets & Mechanisms

EETing away at metastasis

U.S. researchers have shown that antagonizing epoxyeicosatrienoic acids, a type of fatty acid metabolite, reduces tumor growth and metastasis in mice.1 The challenge will be finding a dose that has the desired effect without impairing...
08:00 , Jan 12, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Solid tumors Epoxyeicosatrienoic acids (EETs) Mouse studies suggest antagonizing EETs could help treat solid cancers. EETs are...