BioCentury | Nov 27, 2017
Distillery Therapeutics

Renal

...INDICATION: Renal damage Mouse studies suggest 14,15-epoxyeicosatrienoic acid (EET) or inhibition of its catabolic enzyme EPHX2 could help...
...enzyme EPHX2 could help treat acute kidney injury (AKI). In a mouse model of AKI, 14,15-EET...
...decreased kidney injury and increased survival compared with no treatment. Also in the model, the EET...
BioCentury | Sep 26, 2017
Distillery Therapeutics

Cancer

INDICATION: Breast cancer In vitro , cell culture and mouse studies identified a biguanide-based CYP3A4 inhibitor that could help treat breast cancer. Chemical synthesis and in vitro assays on biguanide analogs identified a compound that inhibited...
BioCentury | Sep 10, 2015
Distillery Therapeutics

Therapeutics: Epoxyeicosatrienoic acid (EET)

...steps could include testing the effects of EETs in additional stem cell transplantation models. TARGET/MARKER/PATHWAY: Epoxyeicosatrienoic acid (EET)...
BioCentury | Jan 23, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Non-small cell lung cancer (NSCLC) Peroxisome proliferation-activated receptor-a (PPARA; PPARa) Mouse studies suggest PPARa agonists could help treat NSCLC. In transgenic mice that develop spontaneous...
BioCentury | Jan 12, 2012
Distillery Therapeutics

Indication: Cancer

...metastasis than normal or low levels of EET. In a mouse lung metastasis model, an EET...
...see EETing away at metastases, page 7). SciBX 5(2); doi:10.1038/scibx.2012.42 Published online Jan. 12, 2012 EET...
BioCentury | Jan 12, 2012
Targets & Mechanisms

EETing away at metastasis

...researchers next asked whether pharmacological modulation of EET activity would alter tumor growth. To increase EET...
...sEH), the enzyme that degrades endogenous EET. To lower EET activity, the team used direct EET...
...optimize the dosing of EET antagonists." Panigrahy and colleagues also will be looking at combining EET...
BioCentury | May 9, 1994
Politics, Policy & Law

White House signals it won't fight; How VCs adjust to threat of price controls

White House signals it won't fight WASHINGTON - A delegation of California biotechnology and health care executives received assurances last week from Ira Magaziner, President Clinton's top advisor on health care reform, that the administration will...
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