20:54 , Dec 19, 2017 |  BC Innovations  |  Distillery Therapeutics

Ophthalmic disease

INDICATION: Diabetic retinopathy Patient samples and mouse studies suggest inhibiting EPHX2 could help treat non-proliferative diabetic retinopathy (NPDR). In postmortem retinal tissue samples from patients, high levels of EPHX2 were associated with disease severity. In...
19:02 , Nov 27, 2017 |  BC Innovations  |  Distillery Therapeutics

Renal

INDICATION: Renal damage Mouse studies suggest 14,15-epoxyeicosatrienoic acid (EET) or inhibition of its catabolic enzyme EPHX2 could help treat acute kidney injury (AKI). In a mouse model of AKI, 14,15-EET decreased kidney injury and increased...
07:00 , Apr 25, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Epoxide hydrolase 2 (EPHX2; CEH) Cell culture and mouse studies suggest a combination of fish oil-derived epoxy docosapentaenoic acids (EDPs) and EPHX2 inhibitors could...
07:00 , Apr 4, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiovascular disease Epoxide hydrolase 2 (EPHX2; CEH) Mouse studies suggest epoxide hydrolase inhibitors could be useful for preventing cardiac fibrosis....
07:00 , Sep 24, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiovascular; inflammation Epoxide hydrolase 2 (EPHX2) In vitro studies identified benzamide-based compounds that could help treat cardiovascular disease. High-throughout screening identified N-(3,3-diphenyl-propyl)-nicotinamide as having...
08:00 , Jan 15, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiac hypertrophy Epoxide hydrolase (EPHX2); angiotensin II type 1 receptor (AGTR1) A study in rats suggests that inhibiting...