BioCentury | Aug 23, 2019
Distillery Techniques

Fecal levels of bacterial genes, metabolite in neonates as childhood allergic disease biomarker

...TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Tissue markers; gene profiling Neonatal fecal abundance of three bacterial epoxide hydrolase genes...
...diseases including asthma, eczema and atopy. In 41 neonates, high fecal levels of three bacterial epoxide hydrolase...
...Lynch, University of California San Francisco, San Francisco, Calif. e-mail: susan.lynch@ucsf.edu Sandi Wong University of California San Francisco Epoxide hydrolase Dermatitis Asthma...
BioCentury | Mar 4, 2019
Distillery Therapeutics

Inhibiting soluble epoxide hydrolase for renal damage

...DISEASE CATEGORY: Renal INDICATION: Renal damage Mouse studies suggest inhibiting soluble epoxide hydrolase could help treat renal...
...could help treat renal damage. In a mouse model of diet-induced renal injury, a soluble epoxide hydrolase...
...Ltd. has TMS-00X, an anti-inflammatory targeting soluble epoxide hydrolase, in preclinical testing for inflammatory disease. TARGET/MARKER/PATHWAY: Epoxide hydrolase...
BioCentury | Nov 9, 2018
Tools & Techniques

HitGen’s DNA for small molecules

...Results were published in June. The single compound with origins in DEL technology was GSK’s epoxide hydrolase...
BioCentury | Dec 19, 2017
Distillery Therapeutics

Ophthalmic disease

...Next steps include testing eyedrop formulations of undisclosed EPHX2 inhibitors in models of NPDR. TARGET/MARKER/PATHWAY: Epoxide hydrolase...
...6, 2017 doi:10.1038/nature25013 CONTACT: Ingrid Fleming, Goethe University Frankfurt, Frankfurt, Germany email: fleming@em.uni-frankfurt.de Hongjiang Li Goethe University Frankfurt Epoxide hydrolase...
BioCentury | Nov 27, 2017
Distillery Therapeutics

Renal

...LLC include planning for Phase I testing of undisclosed EPHX2 inhibitors in renal disease. TARGET/MARKER/PATHWAY: Epoxide hydrolase...
...Liu, Tongji University School of Medicine, Shanghai, China email: jyliu@tongji.edu.cn Hongjiang Li EicOsis LLC Tongji University University of California Davis Epoxide hydrolase...
BioCentury | Apr 25, 2017
Distillery Therapeutics

Dental

...INDICATION: Periodontitis Studies in mice suggest inhibiting epoxide hydrolase could help treat periodontal bone loss. In a...
...treat periodontal bone loss. In a mouse model of bacterial infection-induced periodontitis, a previously reported epoxide hydrolase...
...include testing epoxide hydrolase inhibitors in additional models of periodontitis. GlaxoSmithKline plc has 2256294 , an epoxide hydrolase...
BioCentury | Dec 3, 2015
Targets & Mechanisms

The two faces of LTA4H

...most commonly known for generating the pro-inflammatory leukotriene LTB4 , which it produces via its epoxide hydrolase...
...active site of LTA4H contains distinct regions containing the epoxide hydrolase and peptidase activities. Through its epoxide hydrolase...
...2. Inhibition of the epoxide hydrolase activity suppresses inflammation. LTA4H is primarily known for its pro-inflammatory epoxide hydrolase...
BioCentury | Aug 18, 2014
Strategy

Breathing room

...Deeply Novel Target/MOA AstraZeneca GlaxoSmithKline Novartis (A) CXC chemokine receptor 2 (CXCR2; IL8RB) Ph I Epoxide hydrolase...
BioCentury | Jun 19, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...Licensing status Publication and contact information Cardiovascular disease Hypertension Epoxide hydrolase Mouse studies identified a soluble epoxide hydrolase-dependent...
...components form nitro fatty acids, which inhibit soluble epoxide hydrolase. In mice expressing a mutant soluble epoxide hydrolase...
...epoxide hydrolase activity. Next steps could include further defining the relationship between the extent of soluble epoxide hydrolase...
BioCentury | Apr 25, 2013
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Epoxide hydrolase 2 (EPHX2; CEH) Cell...
...type 2 diabetes before ceasing operations. SciBX 6(16); doi:10.1038/scibx.2013.383 Published online April 25, 2013 Soluble epoxide hydrolase...
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