BioCentury | Dec 8, 2017
Translation in Brief

ADAM and Ephrin

...ADAM10 could treat a form of idiopathic pulmonary fibrosis mediated by the receptor tyrosine kinase ephrin B2...
...the ephrin kinases presents a translational opportunity in ephrin B2 (EFNB2)-mediated IPF. Other groups had previously shown EFNB2...
...in the lung. Through mechanistic studies, the team demonstrated that following lung injury, ADAM10 cleaves EFNB2...
BioCentury | Sep 15, 2016
Targets & Mechanisms

KOR-recting MS

Although the failed Phase II multiple sclerosis trial of Biogen Inc. 's anti-LINGO mAb in June dealt a blow to myelin repair, a slew of compounds acting by different mechanisms lies behind it in clinical...
BioCentury | Aug 11, 2016
Distillery Therapeutics

Therapeutics: Ephrin B2 (EFNB2); zinc finger E-box binding homeobox 2 (ZEB2)

...EFNB2 , could help treat glioblastoma multiforme (GBM). In samples from GBM patients, levels of EFNB2...
...vascular endothelial growth factor (VEGF), to treat brain, breast, colorectal, ovarian and other cancers. TARGET/MARKER/PATHWAY: Ephrin B2 (EFNB2)...
BioCentury | Jul 28, 2016
Distillery Therapeutics

Therapeutics: Ephrin B2 (EFNB2)

...of colony-forming units compared with normal EFNB2 expression. In patient-derived GBM stem cells, shRNA targeting EFNB2...
...EFNB2 in the tumor decreased tumor growth and increased survival. Also in the model, an anti-EFNB2...
...testing small molecule EFNB2 inhibitors in animal models of glioblastoma and other brain cancers. TARGET/MARKER/PATHWAY: Ephrin B2 (EFNB2)...
BioCentury | Aug 13, 2015
Tools & Techniques

Helping Beethoven hear

...to prevent hearing impairments March 2011 Unspecified Hearing loss Jean Defourny, University of Liège Ephrin B2 (EFNB2) EFNB2...
BioCentury | May 7, 2015
Distillery Therapeutics

Therapeutics: Ephrin B2 (EFNB2)

...Other INDICATION: Hearing loss Mouse studies suggest inhibition of EFNB2 could help treat hearing loss by...
...loss by converting cochlear support cells into hair cells in the ear. In newborn mice, EFNB2...
...shRNA. Next steps could include testing EFBN2 inhibition in mouse models of hearing loss. TARGET/MARKER/PATHWAY: Ephrin B2 (EFNB2)...
BioCentury | May 20, 2010
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Ephrin B2 (EFNB2) In vitro and mouse...
...compared with normal EFNB2 expression. Next steps include screening small molecule inhibitors or activators of EFNB2...
BioCentury | Oct 23, 2008
Distillery Therapeutics

This Week in Therapeutics

...Cancer Kaposi's sarcoma Ephrin-B2 (EFNB2); EPH receptor B4 (EPHB4) Studies in mice suggest that inhibiting EFNB2...
...xenografts, a fusion protein consisting of the soluble form of EPHB4, which binds exclusively to EFNB2...
...metastasis. Researchers did not disclose next steps. VasGene Therapeutics Inc. has mAbs targeting EPHB4 and EFNB2...
BioCentury | Apr 30, 2007
Strategy

MedImmune chronicles

...Partners to develop VasGene's preclinical MAbs targeting Eph receptor B4 (EphB4) and its ligand, Ephrin B2 (Efnb2)...
BioCentury | Sep 12, 2005
Company News

MedImmune Inc., VasGene deal

...VasGene partnered to develop VasGene's preclinical MAbs targeting Eph receptor B4 (EphB4) and its ligand, Ephrin B2 (Efnb2)...
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