BioCentury | Feb 16, 2012
Targets & Mechanisms

Still un-sirtuin

...turn stimulates rap guanine nucleotide exchange factor 3 (RAPGEF3; EPAC ) [ b ]. Higher EPAC...
...of cellular energy utilization.Park et al. report that resveratrol inhibited PDE-4 in vitro and stimulated EPAC...
BioCentury | Sep 15, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Colony-stimulating factor 1 receptor (CSF1R; C-FMS; CD115); inhibitor of k light polypeptide gene enhancer in B cells kinase-b (IKBKB; IKK2); rap guanine nucleotide exchange...
BioCentury | Aug 20, 2009
Targets & Mechanisms

New mechanism for sulfonylureas

...SciBX . "And we still don't know how RAP1 affects cellular functioning in different tissues." EPAC's...
BioCentury | Aug 6, 2009
Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Rap guanine nucleotide exchange factor 4 (RAPGEF4; EPAC2); RAP1 GTPase activating protein (RAPGAP; RAP1) Studies in mice identified EPAC2 as the intracellular target...
BioCentury | Feb 26, 2007
Strategy

Hybrigenics escape route

...B.V. (Groningen, the Netherlands) (see BioCentury, Jan. 22). The company also returned assets relating to Epac...
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