21:13 , Apr 17, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling; tissue markers Tumor levels of a panel of 13 glycolysis-related genes could help predict responses to adoptive T cell therapies in melanoma patients. In tumors from an undisclosed number of melanoma patients...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
07:00 , Sep 6, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Enolase 1a (ENO1); enolase 2g neuronal (ENO2) Cell culture studies suggest inhibiting ENO2 in tumor cells could help treat glioblastoma. In ENO1-deficient glioblastoma...
07:00 , Sep 6, 2012 |  BC Innovations  |  Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...