04:21 , Nov 30, 2018 |  BC Innovations  |  Targets & Mechanisms

Adhesion targets emerge at ASH 2018

The next wave of targets in blood cancers and hematology will come from adhesion molecules, innate immune cells and regulators of gene expression, according to BioCentury’s analysis of emerging targets at ASH 2018. BioCentury’s analysis...
19:25 , Oct 11, 2018 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Hypertension Patient sample, cell culture, mouse and rat studies suggest inhibiting ENO1 could help treat pulmonary arterial hypertension (PAH) associated with other conditions. In pulmonary artery smooth muscle cell samples from patients with PAH...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
07:00 , Jun 18, 2015 |  BC Innovations  |  Translation in Brief

Peptide guide to colon cancer

A group in Taiwan has identified a series of peptides that bind with high specificity to enolase 1 α ( ENO1 ) on colorectal cancer (CRC) cells, and could improve tumor targeting of standard chemotherapies....
07:00 , Jun 18, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Enolase 1 α (ENO1)

Cancer INDICATION: Colorectal cancer Cell culture, patient sample and mouse studies suggest conjugates of an ENO1-binding peptide with liposomes containing chemotherapeutics could help treat colorectal cancer (CRC). Phage display-based screening of 12-mer peptides for binding...
07:00 , Sep 6, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Enolase 1a (ENO1); enolase 2g neuronal (ENO2) Cell culture studies suggest inhibiting ENO2 in tumor cells could help treat glioblastoma. In ENO1-deficient glioblastoma...
07:00 , Sep 6, 2012 |  BC Innovations  |  Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...
08:00 , Feb 12, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Pneumonia Enolase-1 (ENO1) In vitro and mouse studies suggest that blocking the binding of ENO1 to plasminogen on monocytes could...