BioCentury | Oct 18, 2012
Cover Story

Taking the fat out of cancer

...endotrophin enhanced both primary tumor growth and metastatic disease. Subsequent experiments suggested a mechanism whereby endotrophin...
...epithelial-mesenchymal transition, which led to increased metastases compared with no endotrophin. In the tumor stroma, endotrophin...
...angiogenesis ( see "Targeting endotrophin in breast cancer"). To test the effects of directly blocking endotrophin...
BioCentury | Oct 18, 2012
Distillery Therapeutics

Indication: Cancer

...information Cancer Breast cancer Endotrophin Mouse studies suggest antagonizing endotrophin could help treat breast cancer. Endotrophin...
...derived from collagen type VI a3 (COL6A3). In a mouse model of aggressive mammary adenocarcinoma, endotrophin...
...to increased tumor volume and lung metastases compared with no overexpression. In mice implanted with endotrophin-overexpressing...
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