17:57 , Feb 15, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neurology Cell culture studies suggest EDN1 or EDN3 could help treat glucose-induced neurotoxicity associated with diabetes. In a rat neural crest cell line stimulated with high levels of glucose, EDN1 or EDN3 decreased levels...
07:00 , Sep 15, 2016 |  BC Innovations  |  Targets & Mechanisms

KOR-recting MS

Although the failed Phase II multiple sclerosis trial of Biogen Inc. 's anti-LINGO mAb in June dealt a blow to myelin repair, a slew of compounds acting by different mechanisms lies behind it in clinical...
07:00 , Apr 14, 2016 |  BC Innovations  |  Translation in Brief

Mending hearts

A collaboration between the Karolinska Institute , Harvard University , Massachusetts General Hospital and other organizations has identified a type of human cardiac progenitor that can rebuild injured heart tissue in mice, and developed a...
08:00 , Dec 4, 2014 |  BC Innovations  |  Tools & Techniques

Roche's heart for diabetes

Building on cardiomyocytes generated from iPS cells by Cellular Dynamics International Inc. , Roche scientists have developed a cell-based model of diabetic cardiomyopathy for use in discovery screening. 1 The cells have the metabolic and...
07:00 , Jun 19, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Dermatology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Dermatology Itch Endothelin 1 (EDN1; ET1); endothelin A receptor; endothelin converting enzyme 1 (ECE1) Mouse and human studies suggest inhibiting endothelin A receptor could help treat...
08:00 , Feb 27, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) Endothelin 1 (EDN1; ET1); endothelin receptor In vitro and mouse studies suggest antagonizing ET1 or endothelin receptor...
07:00 , Apr 18, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) Endothelin 1 (EDN1; ET1); endothelin receptor Patient studies suggest antagonizing ET1 signaling could be useful for treating MS. In patients with...
08:00 , Mar 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Cardiac hypertrophy Endothelin-1 (EDN1; ET-1); inositol 1,4,5-triphosphate receptor 1 (ITPR1; IP3R) In vitro studies suggest that targeting the endothelin...