08:00 , Nov 21, 2013 |  BC Innovations  |  Targets & Mechanisms

Getting to the root of periodontitis

Current periodontitis therapies do not target the underlying immune response that drives the disease. A team from the U.S. and Brazil is looking to change that and has shown that microparticles loaded with chemokine CC...
07:00 , Apr 12, 2012 |  BC Innovations  |  Targets & Mechanisms

DEL1: taking the bite out of periodontitis

An international team of researchers has used the endothelial protein DEL1 to treat periodontitis in mice. 1 Despite the therapeutic angle, the near-term utility of DEL1 is more likely to be as a diagnostic and...
07:00 , Apr 5, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Dental disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Dental disease Periodontitis EGF-like repeats and discoidin I-like domains 3 (EDIL3; DEL1) Human and mouse studies suggest DEL1 could help prevent or treat periodontitis. In patients...
08:00 , Jan 8, 2009 |  BC Innovations  |  Cover Story

Taking the inflammation out of epilepsy

Italian and U.S. researchers have proposed treating epileptic seizures by targeting an inflammatory pathway outside the blood-brain barrier: leukocyte migration and recruitment. 1 The strategy potentially could help patients whose seizures are not adequately controlled...
08:00 , Dec 18, 2008 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

The Distillery: Therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation EGF-like repeats and discoidin I-like domains 3 (EDIL3; DEL1); lymphocyte function-associated antigen 1 (CD11a-CD18) (LFA-1) Studies in mice suggest that increasing...