BioCentury | Jan 18, 2017
Distillery Therapeutics

Autoimmune disease

...Inflammatory bowel disease (IBD); Crohn’s disease Patient sample and mouse studies suggest inhibiting E. coli qseC...
...Crohn’s disease - compared with normal qseC expression. In two mouse models of UC, a qseC...
...identifying and testing E. coli qseC inhibitors in models of Crohn’s disease and UC. TARGET/MARKER/PATHWAY: E. coli sensor protein QseC (qseC)...
BioCentury | Sep 18, 2008
Distillery Therapeutics

This Week in Therapeutics

...and in mice suggest that inhibiting QseC signaling could be useful for treating bacterial infections. QseC...
...Escherichia coli, Salmonella typhimurium and Francisella tularensis, administration of LED209, a substituted benzenesulfonamide that inhibits QseC...
BioCentury | Sep 18, 2008
Targets & Mechanisms

Targeting bacterial virulence

...bacteria, and they have identified a QseC inhibitor that could offer broad-spectrum antibacterial efficacy. 1 QseC...
...a compound involved in bacterial cell-to-cell signaling. Once one of these molecules has been detected, QseC...
...triggers a complex signaling cascade that activates, among other targets, bacterial virulence genes. 2 Blocking QseC...
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