BioCentury | Nov 22, 2017
Preclinical News

Functional assay helps predict patient response to MM therapies

...Further, lower MAR defined sensitivity to an investigational BET inhibitor and a peptide-based inhibitor of E2F transcription factor 1 (E2F1)...
...cancer types. MIT did not respond to inquiries in time for publication. Jennie Walters Massachusetts Institute of Technology E2F transcription factor 1 (E2F1)...
BioCentury | Nov 16, 2017
Tools & Techniques

Internal logic

...not normal cells. The circuit used two transcription factors overexpressed in ovarian cancer, MYC and E2F1...
...to operate only in the presence of two intracellular markers of ovarian cancer, MYC and E2F1...
...both MYC and E2F1, the GAD transcript was rescued by the E2F1-induced transcript. Binding of E2F1...
BioCentury | Sep 14, 2017
Targets & Mechanisms

Platelets YAP at cancer

...MYPT1-PPP1CC axis, a network that produces active nuclear complexes of dephosphorylated YAP1, the transcription factor E2F1...
...domain-containing (TEAD) and E2F1 transcription factors to stimulate a survival program in the cancer cell. E2F1...
...YAP1 mutants in platelet cancer cell co-cultures and showed TEA domain transcription factors and the E2F1...
BioCentury | Feb 14, 2017
Emerging Company Profile

Divide or conquer

...function of the E2F1 pathway when the retinoblastoma protein is absent or not adequately blocking E2F1...
...pathway when the retinoblastoma protein is absent or not adequately blocking E2F1. When PRMT5 methylates E2F1...
...E2F1 is available in cancer cells than in normal cells. He said dysregulation of the E2F1...
BioCentury | Jul 25, 2013
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Melanoma E2F transcription factor 1 (E2F1); tumor protein p73 (TP73...
...acquired resistance to BRAF and MEK inhibitors, methotrexate plus the antifolate prodrug 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin (TMECG) upregulated E2F1...
BioCentury | Mar 12, 2009
Distillery Therapeutics

Indication: Cancer

...In p53-defective human glioblastoma cells, RB1 bound the E2F transcription factor 1 (E2F1) and induced formation of a proapoptotic RB1-E2F1...
BioCentury | Jan 5, 2009
Company News

ArQule, Daiichi Sankyo, Roche deal

...cancer compound ARQ 761. The second-generation compound that selectively targets cancer cells through activation of E2F1-mediated...
...pathways is in Phase II testing. Roche's option to license rights to compounds in ArQule's E2F transcription factor 1 (E2F1)...
BioCentury | Sep 25, 2008
Distillery Therapeutics

This Week in Therapeutics

...in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Colorectal cancer E2F transcription factor 1 (E2F1)...
...flies and in human cell culture suggest that targeting E2F1 could help treat colorectal cancer. E2F1...
...of colorectal cancer and identifying ways to selectively activate E2F1. ArQule Inc.'s ARQ761, which targets E2F1-mediated...
BioCentury | Sep 25, 2008
Targets & Mechanisms

CDK8 is Enough in Colorectal Cancer

...E2F1 activity in fly wing and eye development, a model of β-catenin activation. Overexpression of E2F1...
...expressing an E2F1 knockdown construct. Dyson's group concluded that CDK8 and other Mediator proteins antagonized E2F1...
...leads to inhibition of E2F1, he added. Dyson next plans to examine the effect of E2F1...
BioCentury | Apr 21, 2008
Clinical News

ARQ 761: Phase I start

...trial of IV ARQ 761. Roche has an option to license worldwide rights to ArQule's E2F transcription factor 1 (E2F1)...
...Cancer Molecular target: NA Description: Second-generation compound that selectively targets cancer cells through activation of E2F1-mediated...
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